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NIH Research Project Grant Program - R01 is sponsored by National Institutes of Health (NIH). Supports discrete, specified, and circumscribed research projects in areas representing the specific interests and competencies of the investigator.
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Research Project (R01) | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. The Research Project (R01) is NIH's most commonly used grant program for independent research projects. Are you an early stage investigator (ESI)?
If all the PD/PIs on an R01 (or R01-equivalent ) application have ESI status on the date an application is submitted, the application will be flagged as ESI and will receive special consideration during the review and funding process. See Early Stage Investigator (ESI) Policies to learn more. The Stephen I.
Katz Early Stage Investigator Research Project Grant supports an innovative project in an area of science that represents a change in research direction for an early stage investigator and for which no preliminary data Allowable costs include (but are not limited to): Salary and fringe benefits for Principal Investigator, key personnel, and other essential personnel Alterations and renovations Publications and miscellaneous costs Facilities and Administrative costs (indirect costs) Application and Submission Information R01 Parent Announcements are available.
Not all NIH institutes and centers participate on all parent announcements. Check the participating organization in the funding opportunity before applying. Application Characteristics R01 application budgets are generally not limited but need to reflect the actual needs of the proposed project.
Any opportunity-specific budget limits are indicated in Part 2. Section 2. Award Budget of the funding opportunity.
NIH's Modular Budget Policy applies to R01 applications submitted by domestic organizations. Applications are generally awarded for 1-5 budget periods, each normally 12 months in duration. Applications can be renewed by competing for an additional project period.
After identifying a funding opportunity, follow guidance in the How to Apply – Application Guide instruction call-outs, except where instructed to do otherwise in the funding opportunity or related notices. Standard Due Dates apply. Standard Application Due Dates (when applicable) Participating Funding Organizations Each funding opportunity specifies the participating organizations.
Applications must fit within the mission of at least one participating funding organization and meet all opportunity-specific requirements. The following funding organizations participate on at least one active funding opportunity.
Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs Eunice Kennedy Shriver National Institute of Child Health and Human Development National Cancer Institute National Center for Advancing Translational Sciences National Center for Complementary and Integrative Health National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Biomedical Imaging and Bioengineering National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Environmental Health Sciences National Institute of General Medical Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute on Deafness and Other Communication Disorders National Institute on Drug Abuse National Institute on Minority Health and Health Disparities National Library of Medicine Office of Behavioral and Social Sciences Research Office of Research on Women's Health Office of The Director, National Institutes of Health Tribal Health Research Office Your organization's sponsored programs office or grants administrators can answer many internal and agency policy and process questions.
Understand NIH Staff Roles details how and when to find the right NIH contacts: Before you apply, check your chosen funding opportunity for application submission, scientific/research, peer review, and financial/grants management contacts. After you apply, find NIH staff assignments in the Status module of eRA Commons . For technical issues E-mail OER Webmaster
Key questions and narrative sections extracted from the solicitation.
Specific Aims
Research Strategy
Data Management and Sharing Plan
Scoring criteria used to review proposals for this grant.
According to the current listing, eligibility includes: Nonprofits, Universities, State/local governments. Confirm the full requirements in the official notice before applying.
NIH Research Project Grant Program - R01 is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
The solicitation lists 6 required documents: SF424(R&R), Budget forms, PHS 398 Research Plan, Resource Sharing Plan, Data Management Plan, and Senior/Key Person Profile. Check the official notice for formatting and page-limit rules.
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AHRQ PA-24-261 funds research to determine (1) whether and how breakthrough uses of AI systems affect patient safety in real clinical environments and (2) how AI systems can be safely implemented and used in healthcare delivery. The R18 mechanism funds evaluation - this NOFO explicitly does not support development of new AI systems but rather the rigorous post-deployment evaluation of AI in live clinical settings, complementing AHRQ's broader digital healthcare portfolio. Topics include AI failure mode analysis, alert fatigue from clinical AI, AI-driven diagnostic safety, equity impacts of clinical AI, and human-AI team performance in care delivery. Strong fit for health services researchers, patient safety researchers, and health systems studying AI deployment outcomes.
NCI ITCR Sustained Support U24 (RFA-CA-27-021) sustains widely-adopted cancer informatics technologies in production use by the cancer research community. Funds operational support, user experience improvement, security and accessibility hardening, and continued community engagement for mature AI/ML tools. Examples include cBioPortal, AI cancer imaging platforms, genomic data commons tools, and clinical informatics platforms. Up to $600K direct costs per year for up to 5 years. Strong fit for teams maintaining open-source cancer AI infrastructure with broad user communities.
The NCI ITCR Early-Stage Development U01 funds the design, prototype, and pilot of novel AI/ML-driven informatics technologies that improve acquisition, management, and/or analysis of data across the cancer research continuum. Funded projects include foundation models for cancer pathology, multimodal cancer foundation models, AI-driven clinical decision support, deep learning tumor microenvironment analysis, and AI clinical trial matching tools. Awards provide up to $300K direct costs per year for up to 3 years. Strong fit for academic medical centers, cancer centers, and informatics labs building open-source AI cancer tools. RFA-CA-27-019 reissues the long-running ITCR program through 2027 with multiple receipt dates.
PA-27-037 consolidates the Predoctoral to Postdoctoral Transition Award into a single parent announcement across 20 NIH components, with the next deadline December 8, 2026. The eligibility gate is not the science — it is a mandatory change of institution and mentor between the F99 and K00 phases.
Read articleA draft executive order would have put OMB Director Russell Vought on a commission with final say over NIH awards after peer review. Sen. Collins killed it by pointing at a provision Congress already passed. Here is what the episode teaches applicants about the December 11 cliff.
Read articlePA-27-034, PA-27-035 and PA-27-036 replace the institute-specific R25 announcements that research education programs have been built around for a decade. NCI, NIDA and NIGMS have already expired theirs early. Here is what the consolidation actually changes: an 8% indirect cost ceiling, a US-citizens-and-permanent-residents participant rule, a cooperative agreement variant that only exists on one of the three, and no clinical-trial-allowed companion anywhere.
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