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NIH Transformative Research Award (R01) is sponsored by NIH. Supports exceptionally innovative research projects.
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NIH Director's Transformative Research Award | NIH Common Fund NIH Director's Transformative Research Award NIH Director's Transformative Research Award FY2026 NIH Director’s Transformative Research Award informational video Part of the High-Risk, High-Reward Research program, the NIH Director's Transformative Research Award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
Part of the High-Risk, High-Reward Research program , the award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
Open to all career stages Open to individuals or teams No preliminary data required Research effort commensurate to project needs No prior approval required for large budget requests See the Award Overview for more information.
Application & Award Guide Recent News & Announcements Scientists Discover Possible Anti-Aging Treatment in Mouse Cells A Genetic Checkpoint that Could put Alzheimer’s Disease to REST NIH to award over $207 million to support highly innovative biomedical and behavioral research projects This page last reviewed on
According to the current listing, eligibility includes: Open to all career stages, individuals or teams; no preliminary data required. Confirm the full requirements in the official notice before applying.
NIH Transformative Research Award (R01) is funded by NIH. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
PA-27-037 consolidates the Predoctoral to Postdoctoral Transition Award into a single parent announcement across 20 NIH components, with the next deadline December 8, 2026. The eligibility gate is not the science — it is a mandatory change of institution and mentor between the F99 and K00 phases.
Read articleA draft executive order would have put OMB Director Russell Vought on a commission with final say over NIH awards after peer review. Sen. Collins killed it by pointing at a provision Congress already passed. Here is what the episode teaches applicants about the December 11 cliff.
Read articlePA-27-034, PA-27-035 and PA-27-036 replace the institute-specific R25 announcements that research education programs have been built around for a decade. NCI, NIDA and NIGMS have already expired theirs early. Here is what the consolidation actually changes: an 8% indirect cost ceiling, a US-citizens-and-permanent-residents participant rule, a cooperative agreement variant that only exists on one of the three, and no clinical-trial-allowed companion anywhere.
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