NINDS Research Education Programs for Residents and Fellows in Neurology and Neurosurgery (R25)

NINDS Research Education Programs for Residents and Fellows in Neurology and Neurosurgery (R25) is sponsored by NIH National Institute of Neurological Disorders and Stroke (NINDS). This program supports institutions to develop and implement research education and training programs for clinical residents and fellows in neurological sciences, including neurosurgery, to foster careers as physician-scientists.

Expired RFA-NS-09-001: NINDS Research Education Programs for Residents and Fellows in Neurology and Neurosurgery (R25) This notice has expired. Check the NIH Guide for active opportunities and notices. of Health and Human Services Institutes of Health (NIH), ( http://www.

nih. gov ) Participating Organizations Neurological Disorders and Stroke (NINDS) ( http://www. ninds.

nih. gov ) Education Programs for Residents and Fellows in Neurology and Neurosurgery Applications (RFA) Number: RFA-NS-09-001 Update: The following updates relating to this announcement have been issued: January 30, 2014 - See Notice NOT-NS-14-010. Notification of a Change in Funding Level.

September 20, 2012 - Change in Instructions for Administrative Supplement Requests for the NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology and Neuroradiology (R25). See Notice NOT-NS-12-022. June 10, 2009 - This RFA has been reissued as (RFA-NS-10-002).

June 27, 2008 - See Notice (NOT-NS-08-022) This Notice clarifies four issues regarding this FOA. NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants. gov ( http://www.

grants. gov ) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) APPLICATIONS MAY NOT BE SUBMITTED IN PAPER FORMAT. This FOA must be read in conjunction with the application guidelines included with this announcement in Grants.

gov/Apply for Grants (hereafter called Grants. gov/Apply). A registration process is necessary before submission and applicants are highly encouraged to start the process at least four weeks prior to the grant submission date.

See Section IV . Domestic Assistance Number(s) Release/Posted Date: May 28, 2008 10, 2008 (Earliest date an application may be submitted to Grants. gov) of Intent Receipt Date(s): Not required NOTE : On time submission requires that applications be successfully submitted to Grants.

gov no later than 5:00 p. m. local time (of the applicant institution/organization).

Application Receipt Date(s): September 10, 2008 Peer Review Date(s): November-December, Council Review Date(s): January, 2009 Earliest Anticipated Start Date(s): April , 2009 Additional Information To Be Available Date (URL Activation Date): Not Applicable Expiration Date: September 11, 2008 on Neurological Disorders and Stroke (NINDS) Research Education grant is a flexible and specialized mechanism designed to foster the development of neuroscience researchers through creative and innovative educational programs.

The overall goal of the NINDS research training and research education programs is to ensure that highly trained scientists will make future advances that lead to a reduction in the burden of neurological disease. These research education grants will create an opportunity for medical residents and fellows to participate in an intensive 9 to 24 months of mentored research education experience during residency and fellowship years.

This opportunity will include the necessary training for successful competition for independent mentored research awards and will facilitate the transition from fellow/resident to clinician-scientist. In addition to laboratory research skills, participants in the program will develop the critical skills necessary to design and conduct research experiments and write competitive grant applications. Purpose .

This FOA issued by the NINDS, solicits Research Education Grant (R25) applications from institutions/organizations that propose to support the development and/or implementation of programs that relate to education and training of clinical residents and fellows to foster careers as clinician-scientists.

The PD/PI (see below) must have a staff appointment in a Department of Neurology or Neurosurgery and participants in the research education program must be residents or fellows in neurology, neurosurgery, pathology or radiology. Exceptions to these requirements are not anticipated but may be possible, and must be approved in writing, in advance, by the NINDS Director of Training and Career Development. Mechanism of Support.

This FOA will use the NIH Research Education (R25) grant mechanism. Research education programs may not be transferred from one institution to another. Funds Available and Anticipated Number of Awards.

Up to $1,500,000 per year is available for this program. It is anticipated that between 5 and 15 awards will be made in the first year. Period.

The total project period for an application submitted in response to this funding opportunity may not exceed 5 years. Direct costs for awards made in response to RFA-NS-09-001 may be up to $70,000 per year. Requests for supplemental awards to support additional participants may be requested once per year.

Supplemental requests may be made for up to $70,000 direct costs per additional participant. Requests for supplements are due on September 10 each year of the award, and will not be accepted at Institutions/Organizations. Institutions/organizations listed in Section III, 1.

A. are eligible to apply. This NINDS research education program will only be supported at an accredited Medical School.

Eligible Project Directors/Principal Investigators (PDs/PIs): Individuals with the skills, knowledge, and resources necessary to carry out the proposed research education program are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

The proposed PD/PI must hold a health professional degree (e.g., M. D. , or equivalent), have an appointment in a Neurology or Neurosurgery Department, have clearly demonstrated training/mentoring credentials in research and have a strong recent history of NIH funding.

Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application. Number of Applications.

Applicant departments may only sponsor a single application in response to this FOA. Resubmissions. Resubmission applications are not permitted in response to this FOA.

Renewals. Renewal applications are not permitted in response to this Special Date(s). This FOA uses non-standard due dates.

See Receipt, Review and Anticipated Start Dates Application Materials. See Section IV. 1 for application materials.

General Information. For general information on SF424 (R&R) Application and Electronic Submission, see these SF424 (R&R) Application and Electronic Submission Information: http://grants. nih.

gov/grants/funding/424/index. htm information on Electronic Submission of Grant Applications: http://era. nih.

gov/ElectronicReceipt/ Hearing Impaired. Telecommunications for the hearing impaired are available at: TTY 301-451-5936. Part II Full Text of Announcement Section I.

Funding Opportunity Section II. Award Information 2. Cost Sharing or Matching 3.

Other - Special Eligibility Criteria Section IV. Application and 1. Request Application Information 2.

Content and Form of Application Submission 3. Submission Dates and Times A. Submission, Review, and B.

Submitting an Application Electronically to the NIH C. Application Processing 4. Intergovernmental Review 6.

Other Submission Requirements and Information Section V. Application Review 2. Review and Selection Process A.

Additional Review Criteria B. Additional Review Considerations C. Resource Sharing Plan(s) 3.

Anticipated Announcement and Award Dates Section VI. Award Administration 2. Administrative and National Policy Requirements Section VII.

Agency Contact(s) 1. Scientific/Research Contact(s) 2. Peer Review Contact(s) 3.

Financial/Grants Management Contact(s) Section VIII. Other Information - Required Federal Citations - Full Text of Announcement Section I. Funding Opportunity Description Research Education Objectives Director/Principal Investigator (PD/PI).

The person who writes this application and oversees the entire program. This person must hold a health professional degree (e.g., M. D.

, or equivalent), have an appointment in a Neurology or Neurosurgery Department, and have clearly demonstrated training/mentoring credentials in research and have a strong recent history of Mentors. The mentors will directly train and mentor the participants (residents and fellows) in this research education program.

Mentors must have active, well-funded research programs, and conduct studies in either basic or clinical research related to neurology or neuroscience. Mentors should have a strong track record in the successful training of researchers (as evidenced by continuing success of the trainee in research) and dedication to the training of clinician-scientists.

Mentors can belong to any department or unit, but must conduct research that is directly relevant participants in the research education program are residents and fellows in neurology, neurosurgery, pathology or radiology. Participants must begin this research education program during residency. These participants may then continue in this program during their first fellowship year.

Participants must be dedicated to a career as clinician-scientists, conduct research in an area that fits within the mission of NINDS, and are expected to apply for independent funding by the end of their involvement in this research education program. grant is awarded as a result of the application submitted by the PD/PI The budget for the primary grant award will contain funds for the support of one resident Supplements.

Support for residents and fellows in years 2 5 may be requested by submission of supplement applications. These brief applications, which are described in detail below, should be prepared by the prospective participant, not by the PD/PI of the primary grant . There is one submission deadline (receipt date) per year, September 10 in each of years 2 - 5 during which the primary grant is active.

Supplement applications will be reviewed administratively and will undergo a selection process. Awards will be made based on evaluation criteria and are subject to available funds (details for supplement preparation, submission, review and evaluation criteria are provided below). It is anticipated that there will be more supplement applications than awards.

of the research education program NINDS's research training and research education programs is to ensure that highly trained scientists will be available to make future advances that will lead to a reduction in the burden of neurological disease.

There is critical need for additional clinician-scientists with the medical training and research experience to conduct basic, clinical and translational research on the mechanisms, cure and treatment of neurological disorders.

NINDS provides mentored career development awards (K08 and K23 mechanisms) to highly qualified clinician-scientists who have early training and experience in research, and who generally have one or more significant, original research publications.

However, there is need for a mechanism to support the early training of clinicians during the residency/fellowship period in research and related skills, which would enable them to compete successfully for the mentored career development awards.

This Research Education Program is designed to foster the development of neuroscience researchers through both research training and educational experiences that will prepare clinicians to successfully compete for individual fellowships or mentored career development awards medical school curricula do not traditionally provide skills critical to pursuit of an independent research career, this dedicated opportunity will provide experience in the design and conduct of research, as well as skills required for competitive application for independent funds.

It is expected that participants will conduct basic or clinical research in a well-funded (NIH or comparable) research laboratory and have one or more mentors with a superb track record in the training of clinician-scientists.

Hallmarks of these programs will be the immersion of participants in a significant research problem and an environment that provides high quality mentoring in all aspects of research and career management required for success as a clinician-scientist. The immediate goal of this program is to prepare clinicians to successfully compete for individual fellowships or mentored career development awards.

Such success will facilitate their transition from resident/fellow to clinician-scientist, and will thus foster retention of a cadre of clinician-scientists who will conduct research into the mechanisms of, etiology, and treatment of neurological diseases. Program structure.

Applications will be accepted in response to this funding opportunity from accredited Medical Schools that propose outstanding opportunities for Neurology, Neurosurgery, Pathology and/or Radiology residents and fellows ( participants ) to participate in an intensive, mentored research education experience during residency and fellowship training.

The research education opportunity provided for each individual participant must occur for a minimum 9 month period; participants may be supported by this research education program for a maximum of 24 months. Initial training must take place during a period of 6 - 12 months during residency.

However, once a participant obtains 6 12 months of support from this program during residency, he/she may receive up to 12 months of continued support during fellowship. During any supported period, participants must devote a minimum of 80% of his/her professional time to this research education program (this 80% commitment by the participant should occupy 4 full days during the Monday through Friday workweek).

In general, at least one block of supported time during residency should be a minimum of 6 months in duration, and time committed to this program during fellowship should be continuous. describe in detail the participant activities and commitments not associated with this research experience (e.g. clinical duties, etc.), the time committed to these other activities, and when these activities will occur.

research experiences will be unique and should maximize resources and faculty at the applicant institution. All programs should include extensive laboratory and/or clinical research experience, including the collection of data that can be used by the participant in an application for independent funding.

With the exception of training in experimental design and analysis, in responsible conduct of research, and in grant writing and presentation skills, it is expected that participants will engage in minimal coursework while participating in this research education program. Tuition is not an allowable expense from this FOA. Part of the supported research experience may include travel to one scientific meeting per year.

In addition, all participants are expected to attend an NINDS workshop for either career development awardees or residents. Funds will be provided outside of this FOA for attendance at this workshop (additional details about this workshop will be provided by the NINDS Director of Training and Career Development ). begin this program during residency .

This research education grant is intended to provide a means for participants to begin research education during residency and, if necessary, continue this education during their fellowship period. Consequently, support for any individual participant must begin during residency. Participants who begin this research education program during residency may continue to receive support as part of a research fellowship program.

Participants must commit 80% effort (4 full days during the Monday through Friday workweek) for a minimum period of 6 months during residency in order to be eligible for support during a fellowship period. program success.

The primary indicator of success of these programs will be the ability of participants to successfully compete for individual fellowships or career development awards, and ultimately, the continuation of the participant s research career.

It is expected that applicants will publish original research papers that result from work done during this research education period, but the most important outcome of this research education program will be the successful competition for individual funding for continued career development by the participants. Programs will be evaluated primarily on this outcome to other institutions with similar R25 programs.

In some cases, participants who begin a research education program during residency may wish to change institutions for fellowship training. If the proposed fellowship training institution has an R25 program supported by this FOA, participants who change institutions may request supplemental support to continue in a research education program at the fellowship training institution.

recommended that prospective applicants contact the NINDS Director of Training and Career Development early in the application preparation phase to discuss Such contact will help ensure that applications are responsive to the aims expressed in this announcement. Section VIII, Other Information - Required Federal Citations , for policies related to this announcement.

This FOA will use the NIH Research Education Grant (R25) award mechanism. The Project Director/Principal Investigator (PD/PI) will be solely responsible for planning, directing, and executing the proposed This FOA uses just-in-time concepts (see SF424 (R&R) Application Guide ). It also uses the non-modular budget format.

Applicants must complete and submit budget requests using the SF424 Research and Related (R&R) Budget Component found in the application package for this Because the nature and scope of the proposed research education program will vary from application to application, it is anticipated that the size and duration of each award may vary.

Although the financial plans of the NINDS provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Base (year 1) support for research education programs. The total project period for an application submitted in response to this funding opportunity may not exceed 5 years.

Although the size of the award may vary among research education programs, applications must stay within the following budgetary guideline: direct costs requested in the initial application may be up to $70,000 per participant, annually. In the primary grant, support will be provided to cover salary plus fringe for 80% participant effort (four full days per week), for a period of 9 to 12 months per participant.

Salary support will be calculated as the duration of 80% research effort times the base salary level of the participant. It is anticipated that most programs will initially receive support for one new participant during the first year. Once a grant has been awarded, supplemental requests for support of additional participants may be submitted (see below).

Support for participant travel to one meeting per year may also be requested. Supplemental requests for support in years 2 - 5. Support for participants in years 2 5 will be administered via administrative supplements.

Requests for supplemental funding may be made for one of three reasons. 1) In years 2 5, supplemental funds may be requested to support a new participant, who will begin during residency. This participant must be identified and a brief description of the research education program tailored for this participant must be described.

These supplements will be awarded on a competitive basis, based on suitability of the proposed participant and available funds. 2) Supplements may be requested to continue the training/education during fellowship years of a participant who has completed at least 6 months of support under this FOA during residency. Each participant may receive up to 24 months of support via this funding mechanism.

Whereas these requests will be examined to ensure the continuation of meritorious participants, these requests will not compete with other requests. All participants who begin this program during residency will receive additional support during a research fellowship year, subject to satisfactory progress and an appropriate training/education plan.

3) Some programs may be poised to provide mentoring, training and research education to multiple outstanding residents. Each year, supplemental requests may be submitted for support of additional participants. Supplements may be requested to support participant salary and fringe, plus travel to one meeting, and may not exceed $70,000 direct cost per participant.

There is no limit to the number of participants a program may request support for, but requests on behalf of outstanding candidates from institutions with fewer participants may be given preference. Submission and evaluation of supplemental requests.

Applications will be evaluated administratively, and funds will be allocated, depending on availability of funds, based on evidence of the participant’s potential in research and the program’s record of success in transitioning residents and fellows to independent mentored funding. Applications for supplemental support should be prepared by the prospective participant, not by the PD/PI of the primary application.

Supplement applications must be prepared using the PHS 398 forms . Applications should consist of a 3 page (maximum) description of the research education and research plan. This application must be co-signed by the PD/PI of the primary R25 award and the signing institutional official responsible for administration of the award.

Mentors must be chosen from those listed in the primary application. In addition to the 3 page description, participants should include a curriculum vita, and a letter of support from the proposed mentor that describes the mentoring and research plan for this participant.

Applications for supplemental support to continue in the program in the fellowship year should include, in addition to the 3 page description of future research and training plans, a brief (2 - 3 pages) description of progress made during the residency year.

Whereas the components of the supplement application(except for the letter of support from the proposed mentor) are to be prepared by the prospective participant, the administrative supplement must be submitted by the PD/PI of the primary grant and sent directly to the Chief, NINDS Scientific Review Branch, on paper forms. Facilities and Administrative (F&A) costs requested by consortium participants will not be supported.

All awards are subject to the availability of funds. The estimated amount of funds available for support of projects awarded as a result of this announcement is year amounts will depend on annual appropriations. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

1. A. Eligible Institutions Eligible institutions must have an accredited medical school.

The following organizations are eligible to apply: Public/State Controlled Institutions of Private Institutions of Higher Education Hispanic-serving Institutions Historically Black Colleges and Tribally Controlled Colleges and Native Hawaiian Serving Institutions Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) Domestic organizations with an accredited Medical School that have a scientific and/or educational mission are eligible to submit applications.

Foreign institutions are not eligible to apply in response to this FOA. it is anticipated that the proposed research education program will complement other ongoing research training that occurs at the applicant institution. Institutions with existing Ruth L.

Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving NIH support.

Moreover, the R25 mechanism is not intended to support long-term training by NRSA-eligible individuals and may not be used to circumvent or supplement Ruth L. Kirschstein NRSA research training mechanisms.

Departments that have T32 training grants for the training of clinician-scientists should briefly describe the purpose of those training programs, and provide a detailed explanation of the distinction between intended participants of this research education program and the intended population that would constitute trainees in If multiple sites are involved in the research education program, the applicant institution must be the primary site for the program.

The need for and use of multiple sites must be justified, and the participant’s interaction with individuals at each Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research education program as the Project Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. The PD/PI should be an established investigator in the scientific area in which the application is targeted who is capable of providing both administrative and scientific leadership to the development and implementation of the proposed research education program.

The proposed Principal Investigator must hold a health professional degree (e.g., M. D. , or equivalent), have an appointment in a Neurology or Neurosurgery Department, have clearly demonstrated outstanding training/mentoring credentials in research, and have a strong, recent history of NIH funding .

More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application for projects that require a team science approach and therefore clearly do not fit the single-PD/PI model. Additional information on the implementation plans and policies and procedures to formally allow more than one PD/PI on individual research projects is available at http://grants. nih.

gov/grants/multi_pi . All PDs/PIs must be registered in the NIH electronic Research Administration (eRA) Commons prior to the submission of the application (see http://era. nih.

gov/ElectronicReceipt/preparing. htm for instructions). The decision of whether to apply for a grant with a single PD/PI or multiple PDs/PIs grant is the responsibility of the investigators and applicant organizations and should be determined by the scientific goals of the project.

Applications for grants with multiple PDs/PIs will require additional information, as outlined in the instructions below. The NIH review criteria for approach, investigators, and environment have been modified to accommodate applications involving either a single PD/PI or multiple PDs/PIs.

When considering the multiple PD/PI option, please be aware that the structure and governance of the PD/PI leadership team as well as the knowledge, skills and experience of the individual PDs/PIs will be factored into the assessment of the overall scientific merit of the application. Multiple PDs/PIs on a project share the authority and responsibility for leading and directing the project, intellectually and logistically.

Each PD/PI is responsible and accountable to the grantee organization, or, as appropriate, to a collaborating organization, for the proper conduct of the project or program, including the submission of required reports. For further information on multiple PDs/PIs, please see http://grants. nih.

gov/grants/multi_pi . This program does not require cost sharing as defined Grants Policy Statement . The sponsoring institution must assure support for the proposed research education project.

Appropriate institutional commitment to the project includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education project. The application should include a letter explaining the institutional commitment to the proposed research education program.

Participants : Applicants are required to describe who the intended participants are, and what eligibility and/or specific educational background characteristics are essential for participation in the proposed program. It is expected that participants will be trained in and conduct research in areas that are relevant to the NINDS mission. Support will not be provided for training in areas outside of the NINDS mission.

See also definition under Research Education in Responsible Conduct of Research: Applicants are required to include a plan for Training in the Responsible Conduct of Research (see Section IV. 6). Evaluation and Dissemination Plan : Applications must contain an evaluation plan and a dissemination plan.

Applications submitted without Evaluation and Dissemination plan sections may be delayed in the review process of Applications : Applicant departments may only sponsor a single application Resubmissions : Resubmission applications will Renewals: Renewal applications are not permitted for this Section IV.

Application and Submission Information To download a SF424 (R&R) Application Package and SF424 (R&R) Application Guide for completing the SF424 (R&R) forms for this FOA, link to http://www. grants. gov/Apply/ and follow the directions provided on that Web site.

A one-time registration is required for institutions/organizations at both: Grants. gov ( http://www. grants.

gov/GetStarted ) eRA Commons ( http://era. nih. gov/ElectronicReceipt/preparing.

htm ) PD/PIs should work with their institutions/organizations to make sure they are registered in the eRA Commons. Several additional separate actions are required before an applicant institution/organization can submit an electronic application, as 1) Organizational/Institutional Registration in Grants.

gov/Get will need to obtain a Data Universal Number System (DUNS) number and register with the Central Contractor Registration (CCR) as part of the Grants. gov registration process. does not have a Taxpayer Identification Number (TIN) or Employer Identification Number (EIN), allow for extra time.

A valid TIN or EIN is necessary for CCR validates the EIN against Internal Revenue Service records, a step that will take an additional one to two business days. regarding Grants. gov registration to: Grants.

gov Customer Support Business Hours: M-F 7:00 a. m. - 9:00 p.

m. Eastern Time 2) Organizational/Institutional Registration in the eRA Commons organization is already Commons-registered, see the " List of Grantee Organizations Registered in NIH eRA Commons. regarding the Commons registration to: Phone: 301-402-7469 or 866-504-9552 (Toll Free) Business hours M-F 7:00 a.

m. 8:00 p. m.

Eastern Time 3) Project Director/Principal Investigator (PD/PI) Registration in the NIH eRA Commons: Refer to the NIH eRA Commons System (COM) designated as the PDs/PIs on the application must also be registered in the NIH eRA Commons. In the case of multiple PDs/PIs, all PDs/PIs must be registered and assigned the PD/PI role in the eRA Commons prior to the submission of the PD/PI account in the Commons.

Applicants should not share a Commons account for both an Authorized Organization Representative/Signing Official (AOR/SO) role and a PD/PI role; however, if they have both a PD/PI role and an Internet Assisted Review (IAR) role, both roles should exist under one Commons account. When multiple PDs/PIs are proposed, all PDs/PIs at the applicant organization must be affiliated with that organization.

PDs/PIs located at another institution need not be affiliated with the applicant organization, but must be affiliated with their own organization to be able to access the Commons. This registration/affiliation must be done by the AOR/SO or his/her designee who is already registered in the Commons. and AOR/SO need separate accounts in the NIH eRA Commons since both are authorized to view the application image.

Note that if a PD/PI is also an NIH peer-reviewer with an Individual DUNS and CCR registration, that particular DUNS number and CCR registration are for the individual reviewer only. These are different than any DUNS number and CCR registration used by an applicant organization.

Individual DUNS and CCR registration should be used only for the purposes of personal reimbursement and should not be used on any grant applications submitted to the Several of the steps of the registration process could take four weeks or more. Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered in both Grants. gov and the Commons .

The NIH will accept electronic applications only from organizations that have completed all 1. Request Application Information Applicants must download the SF424 (R&R) application forms and SF424 (R&R) Application Guide for this FOA through Grants. gov/Apply .

Note: Only the forms package directly attached to a specific FOA can be used. You will not be able to use any other SF424 (R&R) forms (e.g., sample forms, forms from another FOA), although some of the "Attachment" files may be useable for more than For further assistance, contact GrantsInfo: Telephone 301-710-0267, Email: [email protected] .

Telecommunications for the hearing impaired: TTY Content and Form of Application Submission using the SF424 (R&R) application forms and in accordance with the SF424 (R&R) Application Guide for this FOA through Grants. gov/Apply . The SF424 (R&R) Application Guide is critical to submitting a complete and accurate application to NIH.

Some fields within the SF424 (R&R) application components, although not marked as mandatory, are required by NIH ( e.g., the Credential log-in field of the Research & Related Senior/Key Person Profile component must contain the PD/PI’s assigned eRA Commons User ID ). Agency-specific instructions for such fields are clearly identified in the Application Guide.

For additional information, see Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications . application has several components. Some components are required, others are optional.

The forms package associated with this FOA in Grants. gov/APPLY