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Office of Science EXPRESS funding opportunity (AI for science, including energy-efficient AI algorithms and hardware) is sponsored by U.S. Department of Energy (DOE) Office of Science. This funding opportunity supports the application of AI for science, with topics covering energy-efficient AI algorithms and hardware for science. It also includes ultra-energy-efficient “neuromorphic” computing for AI.
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Opportunity Listing - The Genesis Mission: Transforming Science and Energy with AI The Genesis Mission: Transforming Science and Energy with AI Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: April 10, 2026 View version history on Grants.
gov DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Grantor contact information GenesisMissionNOFO@science. doe.
gov GenesisMissionNOFO@science. doe. gov GenesisMissionNOFO@science.
doe. gov File name Description Last updated Genesis_Mission_Phase_I_Application_Template_v2. xlsx Phase I Application Template Apr 10, 2026 01:23 PM UTC Genesis_Mission_Phase_II_LOI_Template_v2.
xlsx Phase II LOI Template Apr 10, 2026 01:23 PM UTC Sample_OT_and_Project_Agreements_for_DE-FOA-0003612. pdf Sample OT and Project Agreements Mar 31, 2026 03:33 PM UTC Genesis_Mission_Phase_II_Application_Template. xlsx Phase II Application Template Apr 10, 2026 01:24 PM UTC DE-FOA-0003612.
000003. pdf DE-FOA-0003612 Apr 20, 2026 09:28 PM UTC Link to additional information Closing: December 17, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development
Based on current listing details, eligibility includes: Researchers and institutions focused on AI for science and energy-efficient computing. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Varies Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
Scientific Discovery through Advanced Computing (SciDAC) Institutes is sponsored by U.S. Department of Energy (DOE) Office of Science, Advanced Scientific Computing Research (ASCR). This program supports scientific discovery through advanced computing. While the specific call details for new applications are not explicitly stated as open with a deadline, the program is ongoing and represents a significant funding opportunity for scientific computing research.
Genesis Mission National Science and Technology Challenges is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Critical Minerals and Energy Innovation, Office of Environmental Management, Office of Nuclear Energy, Office of Electricity, and Hydrocarbons and Geothermal Office. This NOFO invites applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks.
Department of Energy SBIR/STTR FY 2026 Phase I, Release 2 is sponsored by U.S. Department of Energy (DOE) Office of Science (SC). The DOE SBIR/STTR programs provide funding for early-stage research and development projects related to energy and other scientific areas. Mandatory Letters of Intent (LOI) must be submitted to be eligible for full proposals.
Research on Circular Economy, Smart Manufacturing, and Energy-Efficient Microelectronics is sponsored by U.S. Department of Energy (DOE) Advanced Materials & Manufacturing Technologies Office (AMMTO). This funding opportunity supports innovative technology R&D across the manufacturing sector with a focus on circular economy, smart manufacturing, and energy-efficient microelectronics. While the stated deadline for full applications has passed, AMMTO frequently issues similar solicitations, and this highlights a relevant area of interest for the DOE.
AWS Imagine Grant program - Momentum to Modernize Award is sponsored by Amazon Web Services (AWS). This award provides funding for transformational infrastructure projects, helping nonprofit organizations enhance their core mission operations with technology. This includes foundational technology projects, such as migrating servers to the cloud and modernizing new and existing applications.