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Office of Science EXPRESS funding opportunity (AI for science, including energy-efficient AI algorithms and hardware) is sponsored by U.S. Department of Energy (DOE) Office of Science. This funding opportunity supports the application of AI for science, with topics covering energy-efficient AI algorithms and hardware for science. It also includes ultra-energy-efficient “neuromorphic” computing for AI.
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Opportunity Listing - The Genesis Mission: Transforming Science and Energy with AI The Genesis Mission: Transforming Science and Energy with AI Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: April 10, 2026 View version history on Grants.
gov DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Grantor contact information GenesisMissionNOFO@science. doe.
gov GenesisMissionNOFO@science. doe. gov GenesisMissionNOFO@science.
doe. gov File name Description Last updated Genesis_Mission_Phase_I_Application_Template_v2. xlsx Phase I Application Template Apr 10, 2026 01:23 PM UTC Genesis_Mission_Phase_II_LOI_Template_v2.
xlsx Phase II LOI Template Apr 10, 2026 01:23 PM UTC Sample_OT_and_Project_Agreements_for_DE-FOA-0003612. pdf Sample OT and Project Agreements Mar 31, 2026 03:33 PM UTC Genesis_Mission_Phase_II_Application_Template. xlsx Phase II Application Template Apr 10, 2026 01:24 PM UTC DE-FOA-0003612.
000003. pdf DE-FOA-0003612 Apr 20, 2026 09:28 PM UTC Link to additional information Closing: December 17, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development
According to the current listing, eligibility includes: Researchers and institutions focused on AI for science and energy-efficient computing. Confirm the full requirements in the official notice before applying.
Office of Science EXPRESS funding opportunity (AI for science, including energy-efficient AI algorithms and hardware) is funded by U.S. Department of Energy (DOE) Office of Science. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Energy Frontier Research Centers (EFRC) program (NOFO: DE-FOA-0003554) is sponsored by U.S. Department of Energy (DOE) Office of Science. This Notice of Funding Opportunity (NOFO) from the Department of Energy's Office of Science aims to accelerate breakthroughs in critical minerals, quantum computing, and advanced manufacturing through fundamental energy technology research.
Energy Frontier Research Centers (EFRCs) (DE-FOA-0003614) is sponsored by U.S. Department of Energy (DOE) Office of Science (SC), Basic Energy Sciences (BES). This program supports fundamental research at Energy Frontier Research Centers to accelerate scientific breakthroughs in areas underpinning energy technologies, including alternative energy. Pre-applications are due April 1, 2026.
NVIDIA Graduate Fellowship Program is a grant from NVIDIA providing up to $60,000 per award to PhD students conducting research that advances accelerated computing and its applications. Now in its 25th year, the program invites nominations from doctoral students pushing the boundaries of artificial intelligence, robotics, autonomous vehicles, and related fields. Recipients receive not only research funding but also access to NVIDIA technology, products, and engineering expertise, along with a mandatory in-person summer internship. Students are nominated by their faculty advisors and selected based on academic achievement and research area alignment.
CalSEED Concept Award is a grant from the California Energy Commission that provides $150,000 in funding to early-stage clean energy innovators in California. The program targets individuals, businesses, and nonprofits developing hardware, software, or integrated solutions at Technology Readiness Levels 2-4. Eligible technology areas rotate each cycle and have included battery recycling and reuse, long-duration energy storage, medium- and heavy-duty vehicle electrification, industrial electrification, and advanced EV charging. Applicants must be located in California, have under $1 million in private funding, and propose innovations that benefit California ratepayers. Concept Award winners also receive professional development resources and access to accelerator programs, and may compete for a subsequent $450,000 Prototype Award.
NIST SBIR Phase I - Advanced Manufacturing and Robotics is sponsored by National Institute of Standards and Technology. NIST SBIR Phase I - Advanced Manufacturing and Robotics is a grant from the National Institute of Standards and Technology (NIST) that funds small businesses with innovative research and technology ideas in advanced manufacturing and robotics.
The Energy Department's flagship Early Career Research Program is funded at $145M for FY2026 — $79M in current-year dollars, the rest contingent on FY27 appropriations. Full applications are due June 2 from the ~150 researchers DOE pre-cleared in March. Here's what the program rewards, why this year's announcement leans hard into Executive Order 14303 on Gold Standard Science, what untenured PIs at academic institutions vs. national labs should expect, and how to position for the FY27 pre-application gate next March.
Read articleThe DOE Genesis Mission RFA closed its Phase II window on May 19. With $293.76M, 21 topics, and 99 focus areas, it is the largest single federal AI-for-science procurement in 2026. Here is what survived the cut and what comes next.
Read articleDOE's Genesis Mission pairs 24 tech giants — Anthropic, Google, OpenAI, NVIDIA — with national labs to apply AI to 26 grand challenges. Phase II applications close May 19.
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