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Open Competition: Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement -- Cycle 3 2026 is sponsored by Patient-Centered Outcomes Research Institute (PCORI). This PFA seeks to fund implementation projects that promote the uptake of peer-reviewed findings from specific PCORI-funded patient-centered comparative clinical effectiveness research (CER) in the context of the body of related evidence.
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Open Competition: Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement | Research Funding Patient-Centered Outcomes Research Institute Open Competition: Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement The Patient-Centered Outcomes Research Institute (PCORI) intends to release an Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement (PFA) on Aug.
4, 2026 , seeking to fund implementation projects that promote the uptake of peer-reviewed findings from specific PCORI-funded patient-centered comparative clinical effectiveness research (CER) in the context of the body of related evidence. This PFA is an open competition opportunity for principal investigators to propose implementation projects that move evidence toward practical use in improving health care and health outcomes.
Applicants may propose projects with budgets up to $1. 8 million in total direct costs.
Letter of Intent (LOI) Deadline For the Cycle 3 2026 PFA, PCORI has identified the following areas of eligible evidence*: Screening and Treatment of Obsessive-Compulsive Disorder in Children and Adolescents Direct Hospital Admissions Programs for Children Early Palliative Care for Patients With Advanced Cancer Caries Arrest and Prevention in Children Medical - Clinical Science
According to the current listing, eligibility includes: This is an Open Competition funding opportunity for principal investigators, including implementation experts and key patient and stakeholder partners. Confirm the full requirements in the official notice before applying.
The published deadline was September 9, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Open Competition: Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement -- Cycle 3 2026 is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Cycle 3 2026 Methods PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI is seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should lead to improvements in the strength and quality of evidence generated by CER studies. For Cycle 3 2026, PCORI has identified "Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER" as a program priority. This directly aligns with developing AI/ML models for risk prediction and stratification.
PCORI launched five simultaneous research funding tracks with $120 million in direct costs for pragmatic studies. Why this non-NIH funder deserves a place in your grant strategy.
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