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"Parent Small Business Innovation Research (SBIR)" is currently closed and not accepting applications.
Parent Small Business Innovation Research (SBIR) is sponsored by NIH (National Institutes of Health). This program provides non-dilutive funding for early-stage research and development to stimulate technological innovation and meet federal R&D needs.
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Small Business Innovation Research Grants (SBIR) - Phase I (R43) | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health Small Business Innovation Research Grants (SBIR) - Phase I (R43) To help small businesses bring scientific innovations to the marketplace. The SBIR supports research and development (R&D) awards to eligible United States small business concerns only.
Note: General Small Business Information Visit Small Business for general guidance, policy, and program information. Find ICO Specific Information Funding Considerations and The focus of a Phase 1 award is on the feasibility, technical merit, and commercial potential of the research project. Carefully read the Eligibility section of the funding opportunity for opportunity-specific organization eligibility requirements.
Project Director/ Principal Investigator (PD/PI) Eligibility PD/PI primary employment (> 50%) should be with the small business. Carefully read the Eligibility section of the funding opportunity for opportunity-specific PD/PI eligibility requirements. Standard Due Dates apply.
Standard Application Due Dates (when applicable) Participating Funding Organizations Each funding opportunity specifies the participating organizations. Applications must fit within the mission of at least one participating funding organization and meet all opportunity-specific requirements. The following funding organizations participate on at least one active funding opportunity.
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs Eunice Kennedy Shriver National Institute of Child Health and Human Development National Cancer Institute National Center for Advancing Translational Sciences National Center for Complementary and Integrative Health National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Biomedical Imaging and Bioengineering National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Environmental Health Sciences National Institute of General Medical Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute on Deafness and Other Communication Disorders National Institute on Drug Abuse National Institute on Minority Health and Health Disparities National Library of Medicine Office of Research on Women's Health NIH SEED: Understanding SBIR and STTR website NIH Grants Policy Statement Section 18.
5 Small Business Innovation Research and Small Business Technology Transfer Programs For technical issues E-mail OER Webmaster
According to the current listing, eligibility includes: Eligible U. S. small businesses. Confirm the full requirements in the official notice before applying.
The published deadline was September 8, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Parent Small Business Innovation Research (SBIR) is funded by NIH (National Institutes of Health). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) is sponsored by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), and Food and Drug Administration (FDA). This program funds small businesses to conduct research and development with commercial potential in health-related technologies. It supports early feasibility through later-stage commercialization.
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) (PA-27-100) is sponsored by National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), and Food and Drug Administration (FDA). This parent announcement supports small businesses in developing innovative health-related technologies, from early feasibility through later-stage commercialization. Applications are accepted three times a year.
PA-27-037 consolidates the Predoctoral to Postdoctoral Transition Award into a single parent announcement across 20 NIH components, with the next deadline December 8, 2026. The eligibility gate is not the science — it is a mandatory change of institution and mentor between the F99 and K00 phases.
Read articleA draft executive order would have put OMB Director Russell Vought on a commission with final say over NIH awards after peer review. Sen. Collins killed it by pointing at a provision Congress already passed. Here is what the episode teaches applicants about the December 11 cliff.
Read articlePA-27-034, PA-27-035 and PA-27-036 replace the institute-specific R25 announcements that research education programs have been built around for a decade. NCI, NIDA and NIGMS have already expired theirs early. Here is what the consolidation actually changes: an 8% indirect cost ceiling, a US-citizens-and-permanent-residents participant rule, a cooperative agreement variant that only exists on one of the three, and no clinical-trial-allowed companion anywhere.
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