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Find similar grantsPatient-Centered Comparative Clinical Effectiveness Research (CER) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI funds patient-centered CER that compares two or more healthcare options to generate evidence that patients, caregivers, clinicians, and the broader healthcare community can use to make better-informed decisions.
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* PCORI's Research Funding Process * What You Need to Know to Apply ### Applicant and Awardee Resources * Research & Related Projects #### Research & Related Projects * CER Results On the Path to Impact * PCORI in the Literature #### Engagement in Research * Foundational Expectations for Partnerships in Research * Foundational Expectations for Partnerships * Background on the Foundational Expectations * Benefits of Engagement in Research * Real-World Examples by Foundational Expectation * Frequently Asked Questions * Why Patient Engagement in Research Matters * The Science of Engagement in Research * Tools and Resources To Support Engagement in Research * Engagement in Health Research Literature Explorer * Engagement Award Program * Get Involved: Participate in the Research Process * Implementation of Evidence #### Implementation of Evidence * Putting Evidence to Work * Evidence Synthesis Reports and Interactive Visualizations * Emerging Topics: Reports and Horizon Scans * Intellectual and Developmental Disabilities * Maternal Morbidity and Mortality * 2026 PCORI Annual Meeting * Financial Statements and Reports * Governing & Operations Documents * Monitoring and Evaluating Progress * Advisory Panel Openings * Application Review and Selection Process * Procurement Opportunities * PCORI's Research Funding Process * What You Need to Know to Apply * Research & Related Projects Toggle Menu * CER Results On the Path to Impact * PCORI in the Literature * Engagement in ResearchToggle Menu * Foundational Expectations for Partnerships in ResearchToggle Menu * Foundational Expectations for Partnerships * Background on the Foundational Expectations * Benefits of Engagement in Research * Real-World Examples by Foundational Expectation * Frequently Asked Questions * Why Patient Engagement in Research Matters * The Science of Engagement in Research * Tools and Resources To Support Engagement in Research * Engagement in Health Research Literature Explorer * Engagement Award Program * Get Involved: Participate in the Research Process * Implementation of Evidence Toggle Menu * Putting Evidence to Work * Evidence Synthesis Reports and Interactive Visualizations * Emerging Topics: Reports and Horizon Scans * Health TopicsToggle Menu * Intellectual and Developmental Disabilities * Maternal Morbidity and Mortality * News & Events Toggle Menu * 2026 PCORI Annual Meeting * Financial Statements and Reports * Governing & Operations Documents * Monitoring and Evaluating Progress * PCORI Advisory PanelsToggle Menu * Advisory Panel Openings * Application Review and Selection Process * Procurement Opportunities # PCORI funds patient-centered comparative clinical effectiveness research (CER) ## Learn about research and related projects PCORI funds ## Include patients and others as partners in research ### Identifying and Treating OCD in Children and Teens: For Parents and Clinicians ### Provide Your Input: Pharmacologic and Nonpharmacologic Treatments for PTSD ### Practical Lessons in Building Organizational Capacity To Engage in Patient-Centered CER ### PCORI is Now Accepting Applications for New Members to Join its Methodology Committee ### Identifying and Treating OCD in Children and Teens: For Parents and Clinicians ### Provide Your Input: Pharmacologic and Nonpharmacologic Treatments for PTSD ### Practical Lessons in Building Organizational Capacity To Engage in Patient-Centered CER ### PCORI is Now Accepting Applications for New Members to Join its Methodology Committee ### Identifying and Treating OCD in Children and Teens: For Parents and Clinicians ### Provide Your Input: Pharmacologic and Nonpharmacologic Treatments for PTSD ### Practical Lessons in Building Organizational Capacity To Engage in Patient-Centered CER ### PCORI is Now Accepting Applications for New Members to Join its Methodology Committee ## #PCORI26: Registration Now Open!
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Intellectual and Developmental Disabilities Maternal Morbidity and Mortality * ### Funding Patient-Centered CER * ### Engaging in the Research Process * ### Disseminating and Implementing the Evidence PCORI funds comparative clinical effectiveness research (CER) that helps people make informed healthcare decisions and improves healthcare delivery and outcomes by producing evidence from research guided by patients, their caregivers and the broader health and healthcare community.
In PCORI-funded research, patients and other interested communities are equitable partners who leverage their lived experience and expertise to influence research to be more patient centered, relevant and useful.
Foundational Expectations for Partnerships in Research Activities to advance the awareness of and use of findings from PCORI-funded research bridge the gap between research and practice to help patients, caregivers and others make better informed health decisions, improve care delivery and patient outcome.
## Get Involved in the Research Process Through opportunities to review research applications, participate on advisory panels, attend workshops, provide public input and other activities, there are many ways to participate. ### Join an Advisory Panel Apply to serve on a PCORI Advisory Panel to help guide research funding priorities and play an integral role in advancing PCORI’s mission.
### Become a Merit Reviewer PCORI invites scientists, patients and others in the healthcare community to serve as reviewers of applications submitted for PCORI funding. ### Become A Peer Reviewer PCORI seeks scientists, patients and others to help ensure PCORI-funded research is held to the highest standards of scientific integrity, relevance and usefulness.
More Ways to Get Involved With PCORI Get weekly updates about opportunities to apply for funding, newly funded research and engagement projects, results of PCORI-funded research, webinars, and other news. 1333 New Hampshire Avenue NW, Suite 1200 Phone: (202) 827-7700 | Fax: (202) 355-9558 * Frequently Asked Questions * Trademark Usage Guidance
According to the current listing, eligibility includes: Researchers and organizations capable of conducting patient-centered comparative effectiveness research. Confirm the full requirements in the official notice before applying.
The current listing shows varies (Example: $19,662,674 for a specific orthopedic trauma surgery study). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Patient-Centered Comparative Clinical Effectiveness Research (CER) is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Cycle 3 2026 Methods PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI is seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should lead to improvements in the strength and quality of evidence generated by CER studies. For Cycle 3 2026, PCORI has identified "Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER" as a program priority. This directly aligns with developing AI/ML models for risk prediction and stratification.
PCORI launched five simultaneous research funding tracks with $120 million in direct costs for pragmatic studies. Why this non-NIH funder deserves a place in your grant strategy.
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