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"Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement (PFA)" is currently closed and not accepting applications.
Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement (PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). This PFA invites applications for high-impact patient-centered comparative clinical effectiveness research (CER). PCORI funds research that helps patients, caregivers, clinicians, policymakers, and other healthcare system stakeholders make better-informed health decisions.
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* **Applicant Town Hall** * **Letter of Intent (LOI) Deadline** April 28, 2026; 5 pm (ET) * **LOI Status Notification** * **Application Deadline** This PCORI Funding Announcement (PFA) invites applications for high impact patient-centered comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, families, caregivers, clinicians, and the health and healthcare community and for which there is insufficient evidence.
Investigators must propose an **individual-level or cluster randomized controlled trial** of significant scale and scope for this PFA. The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions. Proposed studies should compare interventions that already have robust evidence of efficacy and are in current use.
If efficacy is not well established, then widespread use must be documented. Clinical interventions (such as medications, diagnostic tests, or procedures) and delivery system interventions (such as workforce, technologies and healthcare service delivery designs) are appropriate for these studies. Research proposed under this PFA will require two phases of funding.
The initial phase of funding supports a feasibility phase intended for study refinement, infrastructure establishment, patient and stakeholder engagement, and testing of study operations, **including the ability to recruit, enroll and randomize participants successfully**. The feasibility phase must also test intervention delivery and data collection.
Using the feasibility phase to establish evidence of an intervention’s efficacy or effect size is not permitted. Approval to proceed to the full-scale trial phase will be contingent on achieving specific milestones and deliverables established for the feasibility phase.
### Shared Trial Leadership: Data Coordinating Center Considering the scale, complexity and scope of trials being solicited under this PFA, PCORI requires that applications include shared trial leadership by a data coordinating center to provide an independent role in study leadership, advising on the analytical, statistical and data management aspects of both study phases.
### Engagement Resource and Expectations In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making.
Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. View additional details on each of the Foundational Expectations.
Moreover, meaningful patient and stakeholder engagement is viewed as an essential component of funded PLACER studies, and the feasibility phase provides an opportunity to further develop engagement plans and activities. Applicants should include leaders experienced in stakeholder engagement as part of the overall trial leadership in both study phases.
Applicants’ use of multiple approaches that occur along a continuum of engagement from input to shared leadership is encouraged. ### Research Project Agenda Topic Themes Applicants to the Cycle 2 2026 PLACER PFA may select up to three of PCORI’s Research Project Agenda Topic Themes that best align with their proposed research.
Applicants may also opt not to select from the PCORI Research Project Agenda Topic Themes and select “N/A” to indicate that their research aligns with other areas of important need for patient-centered CER. **In keeping with past cycles, the PLACER PFA welcomes all investigator-initiated, patient-centered CER. ** ### Coverage of Patient Care Costs All applicants submitting to this PFA may request coverage of patient care costs.
Coverage of these costs will be subject to meeting specified criteria that PCORI will use to determine which costs, if any, may be acceptable for potential funding. PCORI funding for requested patient care costs is not assured.
Investigators may request up to $2 million in direct costs for a feasibility phase (up to 18 months in duration), with up to $20 million in direct costs for continuation to a full-scale phase (up to five years in duration). Combined direct costs for the full application, including the transition from the feasibility phase to the full-scale study, should not exceed $22 million.
Applications requesting less than $12 million in direct costs will be considered nonresponsive to this PFA. ### Application Deferral Policy The PLACER PFA will not accept deferrals for Cycle 2 2026, as PLACER will not be issued in Cycle 3 2026. The PLACER PFA will be considered for additional issuances in 2027.
For questions regarding the Cycle 2 2026 PLACER funding announcement, please reach out to pfa@pcori. org. * Is Your CER Study Responsive to PCORI’s Funding Announcements?
* What You Need To Know To Apply * Foundational Expectations for Partnerships in Research * PCORI’s Portfolio of Funded Research * Population Insights Reports Powered by PCORnet®") Download Full Announcement Letter of Intent Deadline April 28, 2026, 5 pm (ET) Letter of Intent Status Notification April 2027 (Subject to Change) ## Funds and Project Period -- Feasibility phase: $2 million -- Full-scale study phase: $20 million -- Feasibility phase: 1.
5 years -- Full-scale study phase: five years
According to the current listing, eligibility includes: Academic institutions, nonprofit and for-profit organizations, and governmental entities. Confirm the full requirements in the official notice before applying.
The published deadline was September 1, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement (PFA) is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design. Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research (Cycle 3 2026 Methods PFA) is sponsored by Patient-Centered Outcomes Research Institute (PCORI). PCORI is seeking to fund studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should lead to improvements in the strength and quality of evidence generated by CER studies. For Cycle 3 2026, PCORI has identified "Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER" as a program priority. This directly aligns with developing AI/ML models for risk prediction and stratification.
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