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Open - the parent SBIR announcement was reissued as PA-27-100 (Clinical Trial Optional). The next NIH standard receipt date is January 5, 2027.
Historical funding: Up to approximately $323,090 for Phase I; up to $2,153,927 for Phase II
Prior eligibility: Small businesses with no more than 500 employees, at least 50% U.S. ownership by citizens or permanent residents. The Primary Investigator (PI) must be >50% employed by the small business. For Phase I, >66% of the work must be performed by the small business.
PHS 2023 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) is sponsored by National Institutes of Health (NIH). This program supports small businesses in developing innovative technologies that align with the NIH's mission to improve health. This includes research and development in mental health technologies, digital health, and AI applications. The program encourages proposals that have the potential for commercial success or significant societal benefits.
PAR-27-003 opens the NIGMS-style RM1 to 13 NIH institutes through September 2029: 3 to 6 PIs, up to $1.5M in direct costs a year but most awards $500K to $900K, at least 2.4 months of effort per PI, and a 20-page strategy with a mandatory Team Integration Plan. The NIGMS predecessor made 4 new awards in three years.
Read articleThe October 6, 2026 Director's Awards cohort is NIH's most expensive in four years at about $4.1 million per award. New Innovator rebounded from 29 to 42 while Early Independence fell from 13 to 3 after the program skipped its FY2026 competition. Here is what the composition shift means for FY2027 and FY2028 applicants.
Read articleOn October 7, 2026, Biohub, DOE, NIH, Google DeepMind, Isomorphic Labs and Meta committed $1.8 billion to build AI-ready biological data. More than $500 million of it is DOE money flowing through the Genesis Mission, and NIH's share is data rather than dollars. There is no NOFO — here is where the applyable money actually sits.
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