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PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional) is sponsored by NIH Common Fund. This program seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine.
The 'Translating Model to Clinic' initiative will focus on rigorous AI model building and then evaluate the real-world clinical utility of AI-driven Clinical Decision Support (CDS) tools.
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Opportunity Listing - PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional) PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 310 -- Trans-NIH Research Support Last Updated: May 13, 2026 View version history on Grants.
gov The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions.
The program’s Translating Model to Clinic initiative will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short.
Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.
Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) Public and state institutions of higher education Private institutions of higher education Independent school districts Public and Indian housing authorities Federally recognized Native American tribal governments For-profit organizations other than small businesses Grantor contact information Office of the Director/NIH Common Fund, DPCPSI, OD No documents are currently available.
Link to additional information Estimated Application Due Date : Estimated Due Date Description : Estimated Project Start Date : Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Other Native American tribal organizations; Nonprofits non-higher education with 501(c)(3); Public and state institutions of higher education; Private institutions of higher education; Independent school districts; Public and Indian housing authorities; State governments; Federally recognized Native American tribal governments; County governments; Small businesses; For-profit organizations other than small businesses. Confirm the full requirements in the official notice before applying.
The current listing shows up to $10,200,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
PRIMED-AI: Translating Models to Clinic (UG3/UH3 Clinical Trial Optional) is funded by NIH Common Fund. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
NOT-RM-26-004 asks the public for NIH-wide research challenges worth a 10-year, cross-institute program. There is no budget, no biosketch, no page limit, and no award. What there is: the five criteria every Common Fund investment has met since 2006, a new bullet about small-lab burden, and a fund whose FY 2026 request came in at $347.4 million — down 49.3 percent.
Read articleThe NIH Common Fund launched PRIMED-AI — Precision Medicine with AI: Integrating Imaging with Multimodal Data — as five coordinated funding opportunities (RFA-RM-27-011 through -015) that build a full pipeline from standards to clinic. Here is how the Playbook, Data-to-Model partnerships, Model-to-Clinic translation, Validation Center, and Logistics Center fit together, what each pays, who is eligible, and how to position before the October 2026 deadlines.
Read articleAvoid common NIH grant proposal mistakes including vague specific aims, weak methodology, and poor budget justification that lead to rejection.
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