Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional) is sponsored by NIH Office of Disease Prevention (ODP). Funds research on family health and interventions at the family level.

PAR-25-317: Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute on Minority Health and Health Disparities ( NIMHD ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) National Institute of Nursing Research ( NINR ) National Cancer Institute ( NCI ) Tribal Health Research Office ( THRO ) All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.

The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention ( ODP ) Office of Research on Women's Health ( ORWH ) Funding Opportunity Title Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional) R01 Research Project Grant Notices of Special Interest associated with this funding opportunity January 28, 2026 - NIH Removing AIDS Application Due Dates from NOFOs.

See Notice NOT-OD-26-029 . March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 . August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023.

See Notice NOT-OD-22-198 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 .

Funding Opportunity Number (FON) Companion Funding Opportunity See Part 2, Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93. 307, 93. 313, 93.

399, 93. 273, 93. 361, 93.

310 Funding Opportunity Purpose The purpose of this initiative is to advance the science of minority health and health disparities by supporting research on family health and well-being and resilience. The NIMHD Research Framework recognizes family health, family well-being, and family resilience as important areas of research to decrease disparities and improve outcomes.

Funding Opportunity Goal(s) The goal of this funding opportunity is to support NIMHD's mission to support basic, clinical, social, and behavioral research related to populations experiencing health disparities. Open Date (Earliest Submission Date) The following table includes NIH standard due dates marked with an asterisk.

Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Workspace to prepare and submit your application and eRA Commons to track your application. Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II.

Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description The overarching purpose of this funding opportunity announcement is to solicit innovative multidisciplinary minority health and health disparities research and interventions at the interpersonal level, especially within and at the family level.

While the NIMHD Research Framework identifies interpersonal level factors as one of several levels contributing to minority health and health disparities.

Interpersonal level research studies often focus on health risks and protective factors and health outcomes associated with specific dyads (i.e., parent-child, patient-physician), family environment and experiences (i.e., adverse childhood experiences, sibling, and peer relationships), and across healthcare settings (i.e., family roles in care giving, care management, and health-care related decision-making).

Research on patient populations has centered on the health of the individual or patient level focusing on their condition and treatment or their risk and resilience while ignoring the health and well-being of other family members and the overall health of the family unit.

Outside the caregiving and family studies literature, few studies explore the interaction of family level risk and protective factors (functioning, cohesion or resilience) or family level factors associated with family health outcome measures, such as family well-being, family health behaviors (nutritional practices, health beliefs and practices, physical activity/exercise, preventive screenings, healthcare utilization, or health outcomes).

Research is lacking on how, when, and why families leverage various resources at the neighborhood, community, organizational or health services levels, and how technology or other resources have been leveraged to promote and protect family health or prevent or mitigate internal and external threats to family health or the health of family members.

For the purpose of this funding opportunity, the following definitions are listed below: Family: two or more individuals from populations NIH recognizes as experiencing health disparities . These families share enduring intimate social relationships that may be characterized by blood or legal ties, shared residence, economic cooperation within or across borders, shared responsibilities, and a sense of mutual or collective obligation.

This is inclusive of nuclear, extended, blended, adopted, foster, and chosen families. The goal of this initiative is to support family level health observational and intervention studies in the biomedical, clinical, population, behavioral or social sciences. Projects are expected to include family health measures (i.e., health outcome(s) or behavior(s) measures for 2 or more family members).

Projects must include a focus on families from one or more NIH-designated populations that experience health disparities in the United States. Studies to investigate mechanisms underlying family resilience or susceptibility to disease, observational studies, epidemiologic studies, and family intervention research may utilize tissues and biomarkers from individuals within a family unit.

Studies using animal models will not be supported under this PAR.

Since health disparities are complex, multidisciplinary approaches encompassing multiple domains of influence (e.g., biological, behavioral, socio-cultural, environmental, physical environment) and multiple levels of influence (e.g., individual, interpersonal, neighborhood) to understand and address minority health and health disparities within the context which families are embedded (see the NIMHD Research Framework for more information) are encouraged.

Studies involving primary data collection with human participants are strongly encouraged to incorporate Social Determinants of Health measures from the Core and Specialty collections that are available in the PhenX Toolkit ( www. phenxtoolkit. org ).

Use of these standardized measures for individual demographic factors is required. Projects are encouraged to involve research collaborations with relevant partners, such as community organizations, clinicians, public health, and social and human service organizations, special interest groups, and faith-based organizations.

As appropriate for the research questions posed, involvement of key community members in the conceptualization, planning and implementation of the research is encouraged (but not required) to generate better-informed hypotheses and enhance the translation of the research results into practice.

Specific Areas of Research Interest National Institute on Minority Health and Health Disparities (NIMHD) NIMHD is interested in the following research areas listed below, among others for observational and intervention studies.

Family resiliency, coping, and functioning during extreme stressors (e.g., parental incarceration, suicide, substance abuse, violent behavior, divorce, death of a sibling or child, death of the spouse/partner, physical or mental abuse in a household, migration, and natural and accidental disasters, and public health emergencies).

Examination of family resilience (including religiosity, spirituality, and other shared common values), and coping on future generations, attained educational level and socioeconomic status, and subsequent health outcomes.

Family decision making associated with seeking, accessing, and utilizing internal family and external resources and services (e.g., social support, child support, financial resources, education, food, parenting, and mental health and other health services) to protect, maintain, or promote family health. Family-level determinants of sleep health and sleep disparities.

Biological pathways (e.g., epigenome or microbiome) between family-level stressors and family health. The interaction between family stressors over time and stressors in other domains (e.g., school, work, community) and their impact on family health. The impact of family stressors and resilience strategies and their relationship to family risk for chronic diseases, especially among adults.

Studies addressing the processes and pathways families use to adapt to change in their environments, policies, practices, and procedures and their effect on family health outcomes.

The role and contributions of social and community-based organizations (e.g., community groups, educational activities and educational enrichment programs, team sports, social affinity groups, empowerment activities, volunteer activities, faith-based organizations) on family health outcomes. The influence of family structure, dynamics, and other factors on successful aging and health self-management.

Family-based studies on chronic disease prevention, recommended health screenings, or chronic disease self-management. Research on the effect of the patient/family-clinician relationship or family-health care system communication on clinical and non-clinical outcomes (e.g., clinic attendance, school/work absenteeism). The role of the family-clinician relationship on clinical research participation.

Studies to understand the influence of family health on health pregnancies, maternal morbidity and mortality, postpartum health, and neonatal/infant mortality.

Studies to enhance or facilitate the care of family members with complex medical needs (including children with complex health conditions including developmental disabilities, use of insulin, use or operation of medical devices, care of older adults) and their effect on clinical/health outcomes, including continuity of care, reduction or prevention of complications, and family engagement.

Studies on prompt urgent/emergent health care for the family unit, including preparedness for disasters. The role or timing of family-clinician communication of disease prognosis and care decisions (chronic or long-term care, palliative care, and end-of-life care) while considering sociocultural determinants and religion/spirituality/faith preferences or traditions.

The National Cancer Institute (NCI) NCI supports observational, experimental, and intervention research to understand mechanisms through which family health, family well-being, and family resilience influence cancer along multiple points in the cancer continuum.

These include etiology, prevention, detection, diagnosis, treatment, survivorship, and end-of-life among families of health disparity populations (i.e., segments of the US population that have been typically understudied in biomedical, clinical, behavioral, and social sciences research).

NCI is interested in understanding ways in which family-level, and other factors that affect families (e.g., family health, structures and processes, culture, social support, family dynamics, adverse conditions, stressors, Limited English Proficiency, family separation, migration, coping, resilience, strengths and resources, well-being, and social and developmental contexts, among others) may independently, or interactively with factors influencing cancer prevention and control outcomes in populations with health disparities.

NCI research interests also include interventions targeting families and designed to leverage resources (e.g., community-based, technology, etc.) and improve outcomes along the cancer continuum among populations with health disparities.

Outcomes and topics of primary interest include, but are not limited to: Health behaviors and decision-making integral to effective cancer prevention and control, and for which family relationships and family-level factors are an important determinant, including energy balance (diet, exercise, sedentariness); alcohol consumption; substance use; smoking/tobacco initiation and cessation; and sun safety (e.g., sunscreen use); Sleep and circadian rhythms; Receipt of appropriate cancer screening and surveillance; Receipt of appropriate genetic/ genomic testing and sharing results with family members; Cancer-related health communication within families, or between the family and other entities (e.g., healthcare providers); Decisions about and/ or adherence to cancer prevention (e.g., HPV vaccination), screening, surveillance, treatment regimens, palliative care, survivorship, end-of-life care; Shared decision making in cancer care delivery settings; Cancer care delivery and outcomes such as receipt of guideline concordant care, decisions about where and when to access care, care utilization, and quality of care received; Health outcomes such as symptoms, functioning, and well being; Aging-related consequences of cancer and cancer treatment on symptoms and symptom management; Caregiver outcomes, including health and healthcare utilization, quality of life, psychosocial (e.g., distress, resilience), optimizing use of supportive care resources, and economic outcomes; Whole of family behavior change or adoption or adaptation of evidence-based cancer prevention and control family-based interventions.

The National Institute of Nursing Research (NINR) NINR supports research that advances the prevention, detection, and management of disease and disability for individuals and populations, and informs practice and policy across clinical and community settings.

Drawing on nursing’s holistic, contextualized perspective, NINR funds observational, intervention, and implementation research that integrates factors at multiple levels, including social determinants of health, to identify their role in health, health improvement, and health disparities across many settings, including homes, schools, workplaces, clinics, criminal justice facilities, and the community.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) NIAAA is interested in observational, experimental/intervention, and secondary analysis studies that address family risk and protective factors associated with alcohol misuse and alcohol use disorders (AUD) in multiple interconnected domains (individual, community, and policy), with the goal of developing and implementing effective interventions to improve outcomes in populations that experience health disparities in the U.S. Family level factors are important contributors to alcohol misuse, the course of AUD, and recovery across the lifespan.

Research may address factors associated with spouse, parent, child, and sibling relationships in varied family environments (e.g., same-sex couple, kinship family, single family) and experiences (e.g., separation and divorce, violence, unemployment, child abuse and neglect).

Family-based alcohol prevention and intervention studies in a variety of settings (e.g., healthcare, education, treatment and recovery, and child welfare systems) are encouraged. Areas of interest include, but are not limited to: Family level determinants of alcohol misuse and decision-making related to alcohol use initiation, progression to misuse, AUD treatment, and recovery.

Family impact on the effectiveness of FASD prevention interventions. Family interventions to improve functions and quality of life for individuals with FASD across the lifespan. Family sources of resilience that modify the relationships between stress, alcohol misuse, and AUD.

Family studies of strength and vulnerability to alcohol misuse in the context of whole person health. Family-based youth alcohol use preventive interventions. Family-level interventions to reduce alcohol misuse, facilitate recovery, and improve treatment engagement and outcomes.

Integrative interventions that simultaneously address alcohol misuse/AUD and comorbidities. Long-term effects of child abuse and neglect on alcohol misuse/AUD in adulthood and recovery. Family-based prevention and treatment interventions to mitigate impact of trauma and adverse childhood experiences on alcohol misuse/AUD.

Spirituality, religion, and mutual support groups in family-focused alcohol prevention and treatment interventions. Impacts of changes in parents’ alcohol use patterns and recovery from AUD on parenting and child health and well-being.

The Office of Research on Women’s Health (ORWH) The Office of Research on Women’s Health (ORWH) is part of the Office of the Director, NIH, and works with the 27 NIH Institutes and Centers to advance rigorous research addressing women’s health issues.

ORWH invites applications to supplement active NIH awards from any of the NIH Institutes and Centers (ICs) listed in the announcement to conduct research on women’s health across the lifespan. Structural factors related to Family Health Care from meeting the needs of women of all ages, races, and socioeconomic backgrounds, with a focus on populations of women experiencing health disparities.

Prioritizing women’s health through women’s health innovations to close the gaps and barriers in Family Health Care. Research addressing women’s health needs as a family caregiver. How sex-based violence against women is addressed in Family Health Care.

Tribal Health Research Office (THRO) The Tribal Health Research Office (THRO) serves as the central point of contact at NIH for federally recognized American Indian and Alaska Native (AI/AN) Tribes throughout the United States (U.S.) and is the synergistic hub for all Tribal health research activities and research workforce development at NIH.

The mission of THRO is to improve Native health, enhance capacity for health research in Native communities, and promote opportunities for the next generation of American Indian and Alaska Native (AI/AN) researchers. THRO does not have grant-making authority or administer grants.

The office can only support grants deemed scientifically meritorious after review by one of the institutes or centers (ICs) participating in this announcement and after a co-funding request is initiated through the IC. For this NOFO, THRO is interested in observational and intervention studies examining the role of family health, family well-being, and family resilience toward tribal health.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed The OER Glossary and the How to Apply Application Guide provide details on these application types.

Only those application types listed here are allowed for this NOFO. Optional: Accepting applications that either propose or do not propose clinical trial(s). Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are not limited but need to reflect the actual needs of the proposed project. The scope of the proposed project should determine the project period.

The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized).

Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference the NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM. gov registration process.

The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registrations; all registrations must be in place by time of submission.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants. gov – Applicants must have an active SAM registration in order to complete the Grants.

gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.

If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply-Application Guide. This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2 Definition of Terms .

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed. Instructions for Application Submission The following section supplements the instructions found in the How to Apply- Application Guide and should be used for preparing an application to this NOFO.

All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Project/Performance Site Locations All instructions in the How to Apply- Application Guide must be followed. SF424(R&R) Other Project Information All instructions in the How to Apply- Application Guide must be followed.

SF424(R&R) Senior/Key Person Profile All instructions in the How to Apply- Application Guide must be followed. All instructions in the How to Apply- Application Guide must be followed. All instructions in the How to Apply-Application Guide must be followed.

PHS 398 Cover Page Supplement All instructions in the How to Apply- Application Guide must be followed.

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions: Describe how this project will advance knowledge of family-level health disparities and add to the literature on family level risk and protective factors or family level factors associated with family health outcome measures. Projects are expected to include a detailed conceptual model.

For NIMHD, if there are foreign component(s), describe how the proposed activities at foreign sites will contribute to the knowledge that will improve minority health and/or help to reduce or eliminate health disparities in the United States. Explain how the research team has appropriate expertise in conducting multidisciplinary research without duplicating information in the bio-sketches.

If applicable, describe how the community partners participated in the conceptualization, planning and implementation of the research to inform hypotheses and facilitate translation of the research into practice. Projects are expected to include families from populations experiencing health disparities. Projects are expected to include family level measures and family level research.

Projects are expected to include multiple domains and multiple levels to understand and address minority health and health disparities within the context of families (see the NIMHD Research Framework: https://www. nimhd. nih.

gov/about/overview/research-framework. html ). Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide.

Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply- Application Guide.

All instructions in the How to Apply-Application Guide must be followed, with the following additional instructions: All applicants planning research (funded or conducted in whole or in part by NIH) that results in the generation of scientific data are required to comply with the instructions for the Data Management and Sharing Plan.

All applications, regardless of the amount of direct costs requested for any one year, must address a Data Management and Sharing Plan Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply- Application Guide. No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.

PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply- Application Guide, with the following additional instructions: If you answered “Yes” to the question “Are Human Subjects Involved?

” on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record. Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply- Application Guide must be followed.

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed. PHS Assignment Request Form All instructions in the How to Apply- Application Guide must be followed.

3. Unique Entity Identifier and System for Award Management (SAM) See Part 2. Section III.

1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants. gov 4. Submission Dates and Times Part I.

contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants. gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH’s electronic system for grants administration.

NIH and Grants. gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.

gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications .

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission. Information on the submission process and a definition of on-time submission are provided in the How to Apply-Application Guide. 5.

Intergovernmental Review (E. O. 12372) This initiative is not subject to intergovernmental review.

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement . Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7. 9.

1 Selected Items of Cost. 7. Other Submission Requirements and Information Applications must be submitted electronically following the instructions described in the How to Apply Application Guide.

Paper applications will not be accepted. Applicants must complete all required registrations before the application due date. Section III.

Eligibility Information contains information about registration. For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide . If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance.

For assistance with application