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Find similar grantsThis funding opportunity supports the co-design of learning systems and AI environments that significantly advance the field of AI for public benefit within DOE's mission space.
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Or search similar grants →According to the current listing, eligibility includes: Proposals will be accepted from universities and other eligible organizations. Confirm the full requirements in the official notice before applying.
The current listing shows $150,000 - $2,000,000 (estimated program funding). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Scientific Machine Learning and Artificial Intelligence: Uncertainty Quantification (DE-FOA-0002122) is funded by U.S. Department of Energy (DOE) Office of Science (OS). Verify program details on the funder's official page before applying.
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Past winners and funding trends for this program
FY26 Phase I Genesis Mission Opportunity (SBIR/STTR): Scaling the Biotechnology Revolution is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This SBIR/STTR opportunity, part of the Genesis Mission, supports projects focused on 'Scaling the Biotechnology Revolution' using AI. It aims to accelerate scientific discovery and enhance U. S. leadership in key technologies.
FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program is sponsored by U.S. Department of Energy - Office of Science. Open solicitation for research in Advanced Scientific Computing Research, High Energy Physics, Nuclear Physics, and other areas, including applications of AI and machine learning to fundamental physics and science.
DE-FOA-0003600 is the DOE Office of Science's FY 2026 open, rolling solicitation for financial assistance, providing roughly $500 million across seven program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. AI and machine learning research is supported directly through Advanced Scientific Computing Research, while Biological and Environmental Research funds atmospheric process research, environmental systems process research, and earth-energy systems modeling — making this a major channel for AI-enhanced climate and earth system modeling work. DOE anticipates 200 to 350 new awards ranging from $5,000 to $5 million each, with project periods from six months to five years. The FOA opened September 30, 2025 and accepts applications on a rolling basis through the end of FY 2026.
The Trump administration committed $5B and 278 projects across 15+ agencies to the Genesis Mission. Here's the structure — and how to position for the next wave.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read articleDOE's FY2026 Office of Science open-call solicitation (DE-FOA-0003600) makes roughly $500 million available across about 500 awards of $50,000 to $5 million — across computing, physics, chemistry, biology, fusion, and isotopes — with a rolling window that stays open through September 30, 2026. Unlike a targeted NOFO, it lets investigators propose almost anything within the agency's mission. Here is how the open call actually works, why it is chronically underused, and how to write into it.
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