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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (NIH SEED) is sponsored by National Institutes of Health (NIH) Small business Education and Entrepreneurial Development (SEED). NIH's SEED (Small business Education and Entrepreneurial Development) programs offer non-dilutive funding for early-stage research and development with commercialization potential in the biomedical spectrum.
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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) | National Institute of General Medical Sciences NIH has congressionally mandated set-aside programs for U.S. small businesses to engage in research and development activities that have strong potential for commercialization. Awards are intended to: Stimulate technological innovation. Use small business to meet federal research and development needs.
Increase private sector commercialization of innovations derived from federal research and development. The NIH SBIR/STTR program consists of two phases: Phase 1 (R41/R43) establishes the scientific and technical merit and feasibility as well as the potential for commercialization of the proposed Phase 2 (R42/R44) continues research or research and development (R&D) efforts initiated in Phase 1.
NIH SBIR/STTR grant solicitation announcements and additional information are website. You can also find information on the difference between SBIR and STTR application requirements . NIGMS-Specific SBIR Guidance The goal of NIGMS is to support innovative SBIR projects that could benefit the research communities related to its mission.
SBIR/STTR grant applications are accepted in most of the scientific areas for which the Institute provides support. Specific topics of research interest to NIGMS [PDF] . The NIGMS SBIR program like the vast majority of NIGMS-funded research is investigator-initiated.
Applicants propose what to do, how to do it, and the best path toward commercialization. NIGMS will not accept applications with budget requests exceeding the statutory budget limitations defined in the specific SBIR/STTR notice of considered to fit one or more of the SBA-approved topics for awards over the statutory budget limitations listed in SBA-Approved Waiver Topics of the SBIR/STTR Program Descriptions and Topics .
Applicants who are considering a project with a budget exceeding the hard budget cap defined in the notice of funding opportunity should contact the NIGMS SBIR coordinator early in the process of application preparation and at least six weeks prior to the anticipated submission due date. In all cases, applicants should propose a budget that is reasonable and appropriate for completion of the research project.
NIGMS support of Phase 2B competing renewal grant applications is limited and should be discussed in advance with the NIGMS SBIR coordinator. NIGMS does participate in the Commercialization Readiness Pilot (CRP) program designed to facilitate the transition of previously funded SBIR and STTR Phase 2 and Phase 2B projects to the commercialization stage by providing additional support for technical assistance.
List of NIGMS funding announcements (program announcements, requests for applications and notices) for the SBIR For information about NIGMS SBIR/STTR grants administration and management, NIGMS_GAB_SBIR@nigms. nih. gov .
NIH Research Evaluation and Commercialization Hub (REACH) The NIH Research Evaluation and Commercialization Hub (REACH) program was established to facilitate and accelerate the translation of academic biomedical discoveries into products that improve patient care and public health. Through this program, NIH will provide the qualifying institutions with the funds to seed the creation of academic entrepreneurship Hubs.
Hubs will be responsible for providing innovators with both the initial investment and resources to support the proof-of-concept work and the mentorship in product development and commercialization needed to develop high priority technologies within the NIH’s mission. For more information REACH and current For information about NIGMS SBIR programs, email Eddie Billingslea, Ph. D.
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According to the current listing, eligibility includes: Small business entrepreneurs. Small businesses are eligible to apply to many of NIH's standard programs. Eligibility criteria for SBIR generally include being a for-profit company, primary place of business in the U. Confirm the full requirements in the official notice before applying.
Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (NIH SEED) is funded by National Institutes of Health (NIH) Small business Education and Entrepreneurial Development (SEED). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The April 14 SBIR/STTR reauthorization restarted NIH's small-business pipeline after the shutdown, but the real signal is the sequencing of the new Small Business 101 webinars: program overview June 9, budget July 14, foreign risk August 18.
Read articleAfter a rare gap with zero active omnibus NOFOs, NIH has reissued its SBIR/STTR parent announcements — collapsing four solicitations into two, adding a Strategic Breakthrough bridge and a Commercialization Readiness Pilot, and reopening the funnel with a September 5, 2026 receipt date. Here are the exact solicitation numbers, the new budget ceilings, what actually changed, and how a small business should sequence its submission.
Read articleNOT-OD-26-006 closed all 23 NIH SBIR/STTR opportunities on Nov 17, 2025. The Small Business Innovation and Economic Security Act (S. 3971) was signed April 13, 2026, reauthorizing the program through 2031. NIH posted no active SBIR/STTR NOFOs through early June 2026 while it rebuilt its solicitation suite around new statutory requirements. The September 5 standard receipt date is the first real test of the post-freeze pipeline — here is what the unwind looks like and how to position for it.
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