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Small Business Technology Transfer Grant (STTR) - Phase I (R41) is sponsored by NIH (National Institute of Diabetes and Digestive and Kidney Diseases - NIDDK, and other NIH Institutes and Centers). This is a specific grant mechanism under the NIH STTR program, supporting innovative research by small businesses in collaboration with research institutions, with strong potential for commercialization within NIDDK's scientific areas.
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R41/R42: Small Business Technology Transfer Grant (STTR) - NIDDK R41/R42: Small Business Technology Transfer Grant (STTR) Most recent NIDDK funding announcements: R41/R42 and other Small Business awards The Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR) programs, also known as America's SEED Fund, are a key part of NIH's mission to turn discovery into health.
The statutory purpose of the SBIR program is to strengthen the role of innovative small business concerns (SBCs) in Federally-funded research or research and development (R/R&D).
Specific program purposes are to: (1) stimulate technological innovation; (2) use small business to meet Federal R/R&D needs; (3) foster and encourage participation by emerging and undercapitalized SBCs in technological innovation and, (4) increase private sector commercialization of innovations derived from Federal R/R&D, thereby increasing competition, productivity and economic growth.
In addition to the broad goals of the SBIR program, the statutory purpose of the STTR program is to stimulate a partnership of ideas and technologies between innovative SBCs and non-profit Research Institutions. By providing awards to SBCs for cooperative R/R&D efforts with Research Institutions, the STTR program assists the U.S. small business and research communities by supporting the commercialization of innovative technologies.
The objective of Phase I (R41) is to establish the technical merit and feasibility of the proposed Research/Research & Development efforts and to determine the quality of performance of the small business awardee prior to providing further federal support in Phase II (R42). Please visit our NIDDK SBIR-STTR Programs website for detailed information on scientific program areas and a comprehensive list of resources for grant recipients.
Additionally, find detailed budgetary and programmatic guidance in the current “Program Descriptions and Research Topics” document (PDF, 1. 90 MB) . With appropriate justification from the applicant, the NIDDK may consider budgets that exceed these amounts to support research that aligns with a SBA-approved waiver eligible topic.
The topic should be indicated in the budget justification. The NIDDK also accepts Phase IIB STTR applications from NIDDK Phase II grant recipients and accepts Commercialization Readiness Pilot (CRP) program applications from NIDDK Phase II and IIB grant recipients. Please review the “Program Descriptions and Research Topics” document for additional details, including budgetary guidance.
The table below compares Phase I, Phase II, and Fast-Track application types. Note, the Direct Phase II authority does not apply to the STTR program (see NOT-OD-19-019 ). The NIH SBIR/STTR website also contains Frequently Asked Questions that help delineate differences between these mechanisms.
To support high-risk feasibility projects with a research institution partnership To support continued research & development with a research institution partnership See Phase I and Phase II; allows concurrent review for both applications; shortens review to award process for Phase II Small, for-profit organizations (40% minimum effort) plus research institution partner (30% minimum effort) Small, for-profit organizations (40% minimum effort) plus research institution partner (30% minimum effort) 10% minimum effort for PD/PI 10% minimum effort for PD/PI 10% minimum effort for PD/PI 6 Mo.
to 1 Yr. Phase I; 2-3 Yr.
Phase II; Combination not to exceed 4 years Normally up to $314,363 total costs (DC + F&A + fee) Normally $2,095,748 total costs (DC + F&A + fee) Normally $2,410,111 total costs (Phase I + Phase II; DC + F&A + fee) Facilities and Administrative Costs 40% maximum if no current negotiated rate; NIH will not negotiate for Phase I 40% maximum or current negotiated rate; Grant recipient may negotiate with NIH 7% maximum for grantee organization only 7% maximum for grantee organization only Concurrent Application & Awards Research Experience Required and/or Eligible Degree Yes, to other eligible for-profit small business Yes, to other eligible for-profit small business Yes, to other eligible for-profit small business Abbreviations used: Small Business Concern (SBC), Direct Costs (DC), Facilities & Administrative/Indirect Costs (F&A).
Potential applicants who are considering research involving human subjects are strongly encouraged to contact NIDDK Small Business Program Staff before submission. Please also visit the NIDDK Human Subjects Research page . Total funding support (direct costs, indirect costs, fee) normally may not exceed $314,363 for Phase I awards.
Appropriate budget justification is required. With appropriate justification from the applicant, the NIDDK may consider budgets that exceed these amounts to support research that aligns with a SBA-approved waiver eligible topic (PDF, 376 KB) . Find detailed budgetary and programmatic guidance in the current “Program Descriptions and Research Topics” document (PDF, 1.
90 MB) . Total funding support (direct costs, indirect costs, fee) normally may not exceed $2,095,748 for Phase II awards. Appropriate budget justification is required.
Appropriate budget justification is required. With appropriate justification from the applicant, the NIDDK may consider budgets that exceed these amounts to support research that aligns with a SBA-approved waiver eligible topic (PDF, 376 KB) . Find detailed budgetary and programmatic guidance in the current “Program Descriptions and Research Topics” document (PDF, 1.
90 MB) . Phase II awards are for longer periods and require a commercialization plan. Some projects initiated with SBIR or STTR funding require considerable financing beyond the SBIR and STTR Phase II to achieve commercialization.
NIDDK allows small businesses who have been awarded a NIDDK Phase II SBIR or STTR to submit a Phase IIB (second, sequential Phase II) SBIR or STTR application that will provide additional funding for Phase II SBIR or STTR projects.
These renewals are typically offered for those projects that require extraordinary time and effort, including those requiring regulatory approval or developing complex instrumentation, clinical research tools, and behavioral interventions. Commercial potential (i.e. the probability that an application will result in a commercial product) will be strongly considered in review and making funding decisions.
An applicant's ability to secure substantial independent third-party investor funds will help validate the commercial potential of the proposed Phase IIB project. Applicants are encouraged to secure substantial independent third-part investor funds (i.e., third-party funds that equal or exceed the requested NIH funds).
Find detailed budgetary and programmatic guidance in the current “Program Descriptions and Research Topics” document (PDF, 1. 90 MB) .
Commercialization Readiness Pilot (CRP) Program Institutions/Organizations To receive an STTR grant, the small business concern (SBC) must have a formal collaborative relationship with a research partner at a university or other nonprofit research institutions at least 40 percent of the STTR research project to be conducted by the SBC, and at least 30 percent of the work to be conducted by the single “partnering” research institution.
Additionally, only United States SBCs are eligible to submit STTR applications. An SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets the criteria as described on the NIH SBIR/STTR Small Business Eligibility Criteria page.
Project Directors/Principal Investigators Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.
On an SBIR application, the PD/PI must have his/her primary employment (51% or greater) with the SBC at the time of award and for the duration of the project. Under the STTR Program, primary employment is not stipulated.
The PD/PI may be employed with the SBC or the participating nonprofit research institution if he/she has a formal appointment with, or commitment to, the applicant SBC, which is characterized by an official relationship between the SBC and that individual. There have been updates to application instructions and review language intended to enhance reproducibility through rigor and transparency.
Please visit the Rigor and Reproducibility page for goals, guidance, resources, news, and references. NIH has simplified the policy for late application submission (see NOT-OD-15-039 ). Submit early to ensure receipt by NIH, as staff cannot amend the NIH rules!
All applications are peer reviewed by knowledgeable scientists in the relevant field of research. Contact the appropriate NIDDK Small Business Program Staff . Small Business Programs at the NIH SBIR/STTR Form Registration Page Last Reviewed November 2024
According to the current listing, eligibility includes: Small businesses collaborating with a non-profit research institution on projects relevant to NIDDK's scientific program areas. Confirm the full requirements in the official notice before applying.
The current listing shows see official notice (typically Phase I up to $275,000). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Small Business Technology Transfer Grant (STTR) - Phase I (R41) is funded by NIH (National Institute of Diabetes and Digestive and Kidney Diseases - NIDDK, and other NIH Institutes and Centers). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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