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Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed) is sponsored by NIH (National Institute of Environmental Health Sciences (NIEHS), National Center for Advancing Translational Sciences (NCATS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)). This NOFO invites eligible United States small business concerns to submit SBIR Phase I grant applications to establish the technical merit and feasibility of proposed research and development efforts.
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Opportunity Listing - Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional) Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 866 -- Aging Research 93. 172 -- Human Genome Research 93.
113 -- Environmental Health 93. 839 -- Blood Diseases and Resources Research 93. 213 -- Research and Training in Complementary and Integrative Health 93.
233 -- National Center on Sleep Disorders Research 93. 865 -- Child Health and Human Development Extramural Research 93. 279 -- Drug Use and Addiction Research Programs 93.
840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders 93. 837 -- Cardiovascular Diseases Research 93. 879 -- Medical Library Assistance 93.
173 -- Research Related to Deafness and Communication Disorders 93. 273 -- Alcohol Research Programs 93. 121 -- Oral Diseases and Disorders Research 93.
838 -- Lung Diseases Research 93. 867 -- Vision Research 93. 846 -- Arthritis, Musculoskeletal and Skin Diseases Research 93.
143 -- NIEHS Superfund Hazardous Substances_Basic Research and Education 93. 847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research 93. 859 -- Biomedical Research and Research Training 93.
350 -- National Center for Advancing Translational Sciences 93. 361 -- Nursing Research Last Updated: May 27, 2026 View version history on Grants.
gov The National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC), including the participating Institutes, Centers and Offices, intend to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I, and Fast-Track (NIH only) grant applications for the Small Business Transition Grant.
Through this NOFO, NIH and CDC will support early-career scientists as they transition into entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Applications are not being solicited at this time.
Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R43/R44 activity code.
United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH and CDC awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project.
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir. gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.
Grantor contact information NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER) No documents are currently available.
Link to additional information Estimated Application Due Date : Estimated Due Date Description : Estimated Project Start Date : Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Eligible United States small business concerns (SBCs). Confirm the full requirements in the official notice before applying.
The current listing shows up to $306,872 (NIEHS general applications), up to $173,075 (NIEHS Superfund Research Program), up to $350,000 (NCATS waiver topics). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed) is funded by NIH (National Institute of Environmental Health Sciences (NIEHS), National Center for Advancing Translational Sciences (NCATS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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