Structural Biology of Alzheimer's Disease Related Dementias (ADRDs) Proteinopathies (R01 Clinical Trial Not Allowed)

Bioeconomy policy support hub for Member States, regions and sectors is sponsored by European Commission — Horizon Europe. Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: most Member States and regions [1] have established the bioeconomy as an important policy field. Effective bioeconomy policies and strategies are developed and implemented with specific impact targets in mind; policies and action plans and roadmaps are coordinated across parts of government (e.g. Ministries) and across the quadruple helix (government, sectors, research & innovation, society) to take into account the cross-sectoral and place-based character of the bioeconomy, and the need for a whole of government approach. Platforms are established to facilitate dialogue, experimentation, learning and coordination; all actors of the quadruple helix (e.g. policy makers, NGOs, economic sectors) are aware of the bioeconomy, as well as of the potential and challenges that are specific for their perspective and context. The bioeconomy concept, its principles and its solutions and innovations are mainstreamed by sectors (e.g. food, textiles, chemicals, energy, agriculture, forestry). Scope: Proposals should: establish a European Bioeconomy Policy Support Hub to provide innovative approaches, hands-on support, learning and advise to Member States and regions on plans, roadmaps, policies and collaborations to deploy their bioeconomies; provide innovative tools to assess, on an ongoing basis, the stage of development of bioeconomy policies and strategies in Member States and regions, and to assess the quality of their implementation; provide relevant support, new approaches and recommendations to improve and/or take next steps. Take into account the learnings of the Report “ Deploying the bioeconomy in the EU ” (2021, European Commission), as well as the results of relevant Horizon Europe projects (e.g. ShapingBio, CEE2ACT, SCALE-UP); provide an overview of the uptake of new bioeconomy solutions based on biomass and biological resources (including ecosystems) in European value chains and sectors (including service sectors); provide innovative approaches, hands-on support, learning and advise to Member States and regions to deploy their bioeconomies. This can include activities that aim help to: inform and engage political leadership on the potential of the bioeconomy; establish or improve platforms facilitate policy dialogue, experimentation, learning and coordination (e.g. policy labs); map the bioeconomy’s potential across sectors and society at regional and Member State level, and increase awareness; advance skills of policy makers, and learn from best practices in bioeconomy policy and implementation; set-up or improve local bioeconomy councils, i.e. platforms for dialogue between government, sectors, academia and society (quadruple helix) on bioeconomy policies, plans, roadmaps and their implementation; put in place collaborations that facilitate the scaling-up of bioeconomy solutions in value chains and sectors that are relevant for the Member State or region; monitor the bioeconomy as well as the change process it brings; ensure innovative approaches, hands-on support, learning and advise that is both generic (targeting all Member States and regions; or groups of Member States and regions) and tailormade (in response to questions from specific Member States and regions that express clear need and commitment to collaborate); carry out activities to maximize the geographical spread of its support and advice; enable structural dialogue with European Commission services, and collaborate with relevant initiatives such as the Circular Bio-based Europe (CBE) Joint Undertaking, European University Alliances, the European Circular Economy Stakeholder Platform or the BIOEAST initiative collaborate with such partners on a roadmap to ensure that key results, tools and approaches can be sustained after the end of the project; collaborate with relevant Horizon Europe projects (e.g. ShapingBio) and/or build on their results. The Joint Re Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy Keywords: Bioeconomy, EU research policy /Research policies in the EU, Industrial policy, Innovation policy, Public administration, Advice, Best practice, Member State, Policy support, Region

ARIA's Hypersensory Intelligence programme, directed by Claire Donoghue within the Nature-Inspired Computation opportunity space, is a GBP 65,000,000 bet on establishing the foundations for general-purpose olfactory perception at or beyond biological performance. The Technical Area 1 call now open is the data-generation layer of that bet and is the most tractable entry point for machine learning teams: ARIA is funding up to six teams, at up to GBP 500,000 each, to construct the Open Olfactory Resource, described as the world's largest open, cross-domain dataset of volatile chemical signals. The framing should be read carefully by AI groups, because this is a dataset-construction call rather than a modelling call - the deliverable is an open resource that later technical areas and the wider field will train on. That makes it unusually attractive to teams with instrumentation, analytical chemistry or high-throughput data-collection capability paired with ML data-engineering skill, and correspondingly less suited to a pure modelling group with no route to generating volatile chemical measurements. The strategic argument for engaging now is positional: teams that build the resource understand its structure, its failure modes and its coverage gaps better than anyone, which is a durable advantage when ARIA funds the perception and modelling technical areas that follow. Full proposals for TA1 close 30 September 2026.

PAR-26-040 is the National Library of Medicine's standing R01 vehicle for bioinformatics, translational bioinformatics and computational biology, and it is one of the more accessible NIH entry points for AI and machine learning work on biomedical data. The NOFO explicitly names artificial intelligence, machine learning and large-scale computational platforms among the transformative technologies it seeks to leverage for extracting actionable knowledge from vast, diverse and complex biological datasets, and it calls out studies that use AI and ML applications for predictive and analytical bioinformatics research as being in scope. That explicit language is worth noting, because AI-heavy proposals submitted to general biomedical NOFOs frequently draw reviewer objections that the methods work is not the point of the call; here it is. Three structural features make this an unusually practical target. First, it is a parent-style PAR with multiple rolling due dates running from 5 June 2026 through 5 February 2029 and an expiration of 6 March 2029, so there is no single make-or-break deadline and a resubmission has somewhere to go. Second, eligibility is broad - higher education institutions, nonprofits, for-profits including small businesses, state, local, federal and tribal governments, and foreign entities are all eligible, and cost sharing is not required. Foreign institution eligibility in particular is not universal across NIH NOFOs and is a genuine differentiator. Third, clinical trials are optional and human subjects involvement is optional, so purely computational projects are fully within scope rather than being penalised for lacking a clinical arm. The trade-off is budget scale: 250,000 dollars per year in direct costs over at most 4 years is modest for an R01 and rules out large data-generation components. This is a fit for method development, tool building and secondary analysis, not for assembling new cohorts.