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The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is sponsored by U.S. Department of Energy (DOE) Office of Science. This funding opportunity supports research teams using artificial intelligence (AI) to tackle complex national scientific and energy challenges, including biotechnology, advanced manufacturing, critical materials, quantum information science, and nuclear energy.
It is part of the agency's broader Genesis Mission initiative, bringing together interdisciplinary teams from national laboratories, universities, and the private sector to accelerate scientific discovery.
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GRANTS The Genesis Mission: Tra...
| U.S. DOE Office of Science(SC) The Genesis Mission: Transforming Science and Energy with AI DE-FOA-0003612 (updated April 20, 2026) Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production Thursday, December 17, 2026 Submission Deadline for FY26 Phase I Applications: May 1, 2026, at 11:59 PM Eastern (grants.
gov) Submission Deadline for FY26 Phase II Letters of Intent: May 1, 2026, at 5 PM Eastern (PAMS) Submission Deadline for FY26 Phase II Applications: May 19, 2026, at 11:59 PM Eastern (grants. gov) Submission Deadline for Phase II Applications resulting from FY26 Phase I Awards: December 17, 2026, at 11:59 PM Eastern (grants. gov) A Phase I Application Template is available here .
A Phase II Letter of Intent Template is available here. A Phase II Application Template is available here. Sample OT and Project Agreements are available here.
A document of Frequently Asked Questions is provided (updated April 27, 2026).
Genesis Mission: Informational Webinars The Genesis Mission: Transforming Science and Energy with AI DE-FOA-0003612 (updated April 20, 2026) Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production Thursday, December 17, 2026 Submission Deadline for FY26 Phase I Applications: May 1, 2026, at 11:59 PM Eastern (grants.
gov) Submission Deadline for FY26 Phase II Letters of Intent: May 1, 2026, at 5 PM Eastern (PAMS) Submission Deadline for FY26 Phase II Applications: May 19, 2026, at 11:59 PM Eastern (grants. gov) Submission Deadline for Phase II Applications resulting from FY26 Phase I Awards: December 17, 2026, at 11:59 PM Eastern (grants. gov) A Phase I Application Template is available here .
A Phase II Letter of Intent Template is available here. A Phase II Application Template is available here. Sample OT and Project Agreements are available here.
A document of Frequently Asked Questions is provided (updated April 27, 2026). Genesis Mission: Informational Webinars U.S. Department of Energy SC-43/Germantown Building 1000 Independence Ave. , SW sc.
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According to the current listing, eligibility includes: Universities, national laboratories, private companies, and academic research organizations, with an emphasis on collaborative, multi-institution teams. Federally affiliated entities, including DOE national laboratories and federally funded research centers, are eligible to participate as team members. Confirm the full requirements in the official notice before applying.
The current listing shows up to $750,000 (Phase I); Up to $15,000,000 (Phase II). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) are due December 17, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is funded by U.S. Department of Energy (DOE) Office of Science. Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Past winners and funding trends for this program
DE-FOA-0003665, the Office of Science Open Call, accepts applications any day until September 30, 2027. But six program offices run their own comparative review panels on their own dates, and a proposal that arrives after a panel's acceptance date waits a year. Here is how to read the hidden calendar.
Read articleThe Trump administration committed $5B and 278 projects across 15+ agencies to the Genesis Mission. Here's the structure — and how to position for the next wave.
Read articleOn July 22, 2026, the White House announced more than $5 billion in federal commitments for the Genesis Mission — the Department of Energy-led national initiative to fuse AI, exascale computing, and the 17 national labs into a single scientific platform. Nearly 300 projects across all 50 states were selected from a historic Request for Applications, and 15-plus agencies are now attaching funding to a set of National Science and Technology Challenges. Here is what the Genesis Mission is, how the money is structured, and the concrete on-ramps for researchers, universities, and small businesses who were not in the first cohort.
Read article