Translational Digital and Computational Psychiatry Program

Translational Digital and Computational Psychiatry Program is sponsored by National Institute of Mental Health (NIMH), National Institutes of Health (NIH). The program fosters innovative computational approaches to identify and validate novel mechanisms, biomarkers, and treatment targets for the prevention and treatment of psychiatric disorders.

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Call or Text 988 Transforming the understanding and treatment of mental illnesses. Home|Help for Mental Illnesses * Mental Health Information ## Health Topics NIMH offers expert-reviewed information on mental disorders and a range of topics. ## Statistics NIMH statistics pages include statistics on the prevalence, treatment, and costs of mental illness for the population of the United States.

## Brochures and Fact Sheets Download, read, and order free NIMH brochures and fact sheets about mental disorders and related topics. ## Help for Mental Illnesses If you or someone you know has a mental illness, there are ways to get help. Use these resources to find help for yourself, a friend, or a family member.

## Clinical Trials If you or a friend or family member are thinking about taking part in clinical research, this page contains basic information about clinical trials. ## Stakeholder Engagement Find out how NIMH engages a range of stakeholder organizations as part of its efforts to ensure the greatest public health impact of the research we support.

## Research Funded by NIMH NIMH supports research at universities, medical centers, and other institutions via grants, contracts, and cooperative agreements. Learn more about NIMH research areas, policies, resources, and initiatives. ## Research Conducted at NIMH (Intramural Research Program) The Division of Intramural Research Programs (IRP) is the internal research division of the NIMH.

Over 40 research groups conduct basic neuroscience research and clinical investigations of mental illnesses, brain function, and behavior at the NIH campus in Bethesda, Maryland. Learn more about research conducted at NIMH. ## Priority Research Areas Learn about NIMH priority areas for research and funding that have the potential to improve mental health care over the short, medium, and long term.

## Resources for Researchers Information about resources such as data, tissue, model organisms and imaging resources to support the NIMH research community. ## Application Process Explore the NIMH grant application process, including how to write your grant, how to submit your grant, and how the review process works. ## Managing Grants Learn about how NIMH manages research grants, including policies and reporting requirements.

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D. ## Advisory Boards and Groups Read about the boards and groups that advise and provide guidance to the Institute. ## Offices and Divisions Learn more about the functions of each NIMH office and division.

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## History Explore key milestones, discoveries, and the impact of NIMH-funded studies on mental health. ## Getting to NIMH Find directions, maps, parking information, and other visitor information for NIMH.

**Contribute to Mental Health Research** * Mental Health Information * Mental Health Information Home * Brochures and Fact Sheets * Help for Mental Illnesses * Research Funded by NIMH * Research Conducted at NIMH (Intramural Research Program) * Opportunities & Announcements * Strategy for Research Grants * Grant Writing & Approval Process * Research Training and Career Development Opportunities * Small Business Research * Innovation Speaker Series * About the Acting NIMH Director * Advisory Boards and Groups * About the Acting NIMH Director * Advisory Boards and Groups Home>About NIMH>Offices and Divisions>Division of Translational Research (DTR)>Adult Psychopathology and Psychosocial Interventions Research Branch>Translational Digital and Computational Psychiatry Program [](https://www.

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gov%2Fabout%2Forganization%2Fdtr%2Fadult-psychopathology-and-psychosocial-interventions-research-branch%2Ftranslational-digital-and-computational-psychiatry-program) * Adult Psychopathology and Psychosocial Interventions Research Branch * Adult Pathophysiology and Biological Interventions Development Branch * Developmental Mechanisms and Trajectories of Psychopathology Branch * Geriatrics and Aging Processes Research Branch * Biomarker and Intervention Development for Childhood-Onset Mental Disorders Branch * Traumatic Stress Research Program * Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program (Adult Psychopathology) * Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program (Child Psychopathology) * Office of Research Training and Career Development # Translational Digital and Computational Psychiatry Program The overarching goal of this program is to foster innovative computational approaches to identify and validate novel mechanisms, biomarkers, and treatment targets relevant to the prevention and treatment of psychiatric disorders.

The program supports research projects that use advanced computational methods with behavioral, biological, and/or clinical data to decipher complex mechanisms involved in mental disorders and to conduct initial tests of novel tools to predict risk, clinical trajectories, and treatment response.

Toward these goals, the program also supports translational research focused on novel computational approaches to dissecting the heterogeneity of mental disorders and the use of computational models for validating Research Domain Criteria (RDoC) constructs in clinical populations.

The program encourages the development and testing of novel tools that modulate mental health treatment targets or enhance the precision of mental health assessments through the use of passive and active sensing devices. It also focuses on research and development of novel computational methods used in the diagnosis, treatment, and prevention of various forms of psychopathology.

Consistent with the focus of the branch on adult psychopathology applications assigned to this program address anxiety and mood disorders, personality pathology, and psychosis in adults 18 years of age and older.

Computational methods in this program typically involve research translating basic science knowledge to discover phenotypic characterization, etiology, pathophysiology, trajectory, risk and resilience, and develop efficacious interventions for mental health conditions. Thesetranslational research studies include software-based tools being tested for early-stage efficacy, typically phase I/II Clinical Trials.

* Translational efforts to use computational models of fundamental neurobehavioral, cognitive, and affective processes to understand mechanisms underlying mental disorders. * Biologically realistic and integrative models incorporating genetic, molecular, cellular, neural, behavioral, and other data to identify psychopathology phenotypes that transcend heterogeneous diagnostic categories.

* Development of novel translational tools for digital phenotyping, including those that use device-based data collection methods, information harvested from multiple data sources, and multi- modal approaches.

* Early-stage development and initial tests of precision psychiatry approaches that employ novel data science tools, including artificial intelligence and machine learning, to improve the accuracy of individual-level predictions of treatment response and clinical trajectories, including efforts to reduce bias in such approaches.

* Early-stage development and testing of novel tools to perform functions such as clinical decision support,computer-assisted detection/diagnosis, companion diagnostics, digital therapeutics, and remote patient monitoring. * Application leveraging novel computational/mHealth/digital health technology to study etiology, pathophysiology, course and trajectories of mental health problems.

Please note that inquiries regarding grant applications focused on the use of computational methods in real-world practice settings and communities, aiming to improve public health through research related to the late-stage efficacy and effectiveness of existing interventions and innovations for improving clinical practice (e.g., phase III/IV Clinical Trials) should be directed to theDivision of Services and Interventions (DSIR).

* Anxiety Disorders Research Program * Translational Digital and Computational Psychiatry Program * Eating Disorders Research Program * Mood Disorders Research Program * Psychotic Disorders Research Program * Social Neuroscience and Communication in Adult Psychopathology Program * Statistical Methods in Psychiatry Program Brochures and Fact Sheets ##### Policies and Notices National Institutes of Health (NIH) U.S. Department of Health and Human Services The National Institute of Mental Health (NIMH) is part of NIH, a component of the U.S. Department of Health and Human Services.